Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer

Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer

Triple-negative breast cancer (TNBC) represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes. Hence, new molecular targets for therapeutic intervention are necessary. Analyses of panels of human or mouse cancer lines derived from the same individual...

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Bibliographic Details
Main Authors: Cameron N. Johnstone, Andrew D. Pattison, Kylie L. Gorringe, Paul F. Harrison, David R. Powell, Peter Lock, David Baloyan, Matthias Ernst, Alastair G. Stewart, Traude H. Beilharz, Robin L. Anderson
Format: Article
Language:English
Published: The Company of Biologists 2018-05-01
Series:Disease Models & Mechanisms
Subjects:
Triple-negative
Breast cancer
Metastasis
Mouse model
Xenograft
Online Access:http://dmm.biologists.org/content/11/5/dmm032250

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