Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST)
To evaluate the feasibility of an individualized exercise program in the standard care for endometrial cancer patients aimed to improve quality of life and other health outcomes. This was a single-arm prospective intervention trial to assess the feasibility of an individualized exercise intervention...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/22/5579 |
| _version_ | 1797465695626199040 |
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| author | Anke Smits Khadra Galaal Steve Winnan Alberto Lopes Ruud L. M. Bekkers |
| author_facet | Anke Smits Khadra Galaal Steve Winnan Alberto Lopes Ruud L. M. Bekkers |
| author_sort | Anke Smits |
| collection | DOAJ |
| description | To evaluate the feasibility of an individualized exercise program in the standard care for endometrial cancer patients aimed to improve quality of life and other health outcomes. This was a single-arm prospective intervention trial to assess the feasibility of an individualized exercise intervention in endometrial cancer patients after treatment. The exercise intervention consisted of weekly individualized training sessions, for 10 weeks, at a local gym facility. The program started six weeks post-operatively. Primary outcomes were feasibility aspects including number of eligible patients, recruitment and adherence rates. Secondary outcomes included quality of life outcomes and anthropometric measures. A total of 54 women were eligible for participation, of which 22 (41%) consented to the study. Overall attendance was 86%, and there were no adverse events. There was a significant improvement in quality of life outcomes, including role (<i>p</i> = 0.02), emotional (<i>p</i> = 0.02) and cognitive functioning (<i>p</i> = 0.04). In addition, there was a significant improvement in visceral fat percentage (<i>p</i> = 0.039) and physical fitness (six-minute walk test <i>p <</i> 0.001). The maximum weight loss achieved was 6.0 kg after 3 months and 8.4 kg after 6 months. An individualized one-to-one exercise intervention in endometrial cancer patients is feasible in terms of recruitment, adherence and safety. |
| first_indexed | 2024-03-09T18:26:09Z |
| format | Article |
| id | doaj.art-2dd7d41dc5aa4d36a164d53b64122800 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T18:26:09Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2dd7d41dc5aa4d36a164d53b641228002023-11-24T07:53:30ZengMDPI AGCancers2072-66942022-11-011422557910.3390/cancers14225579Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST)Anke Smits0Khadra Galaal1Steve Winnan2Alberto Lopes3Ruud L. M. Bekkers4Gynecological Oncology, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The NetherlandsGynecological Oncology, Sultan Qaboos Comprehensive Cancer Care and Research Centre, Seeb 999046, OmanRoyal Cornwall Hospital Trust, Penryn TR10 9FE, UKGynecological Oncology, Royal Cornwall Hospital Trust, Truro TR1 3HD, UKGynecological Oncology, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The NetherlandsTo evaluate the feasibility of an individualized exercise program in the standard care for endometrial cancer patients aimed to improve quality of life and other health outcomes. This was a single-arm prospective intervention trial to assess the feasibility of an individualized exercise intervention in endometrial cancer patients after treatment. The exercise intervention consisted of weekly individualized training sessions, for 10 weeks, at a local gym facility. The program started six weeks post-operatively. Primary outcomes were feasibility aspects including number of eligible patients, recruitment and adherence rates. Secondary outcomes included quality of life outcomes and anthropometric measures. A total of 54 women were eligible for participation, of which 22 (41%) consented to the study. Overall attendance was 86%, and there were no adverse events. There was a significant improvement in quality of life outcomes, including role (<i>p</i> = 0.02), emotional (<i>p</i> = 0.02) and cognitive functioning (<i>p</i> = 0.04). In addition, there was a significant improvement in visceral fat percentage (<i>p</i> = 0.039) and physical fitness (six-minute walk test <i>p <</i> 0.001). The maximum weight loss achieved was 6.0 kg after 3 months and 8.4 kg after 6 months. An individualized one-to-one exercise intervention in endometrial cancer patients is feasible in terms of recruitment, adherence and safety.https://www.mdpi.com/2072-6694/14/22/5579endometrial cancerexercisefeasibilityquality of lifeweightfitness |
| spellingShingle | Anke Smits Khadra Galaal Steve Winnan Alberto Lopes Ruud L. M. Bekkers Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST) Cancers endometrial cancer exercise feasibility quality of life weight fitness |
| title | Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST) |
| title_full | Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST) |
| title_fullStr | Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST) |
| title_full_unstemmed | Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST) |
| title_short | Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST) |
| title_sort | feasibility and effectiveness of the exercise program in endometrial cancer feasibility and acceptability survivorship trial epec fast |
| topic | endometrial cancer exercise feasibility quality of life weight fitness |
| url | https://www.mdpi.com/2072-6694/14/22/5579 |
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