Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis
PurposeThis study aims to evaluate the accuracy of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in distinguishing malignant and benign solitary pulmonary nodules and masses.MethodsStudies investigating the diagnostic accuracy of IVIM-DWI in lung lesions published through Decemb...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2022-06-01
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Series: | Frontiers in Surgery |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.817443/full |
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author | Yirong Chen Yirong Chen Qijia Han Zhiwei Huang Zhiwei Huang Mo Lyu Mo Lyu Zhu Ai Yuying Liang Haowen Yan Mengzhu Wang Zhiming Xiang |
author_facet | Yirong Chen Yirong Chen Qijia Han Zhiwei Huang Zhiwei Huang Mo Lyu Mo Lyu Zhu Ai Yuying Liang Haowen Yan Mengzhu Wang Zhiming Xiang |
author_sort | Yirong Chen |
collection | DOAJ |
description | PurposeThis study aims to evaluate the accuracy of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in distinguishing malignant and benign solitary pulmonary nodules and masses.MethodsStudies investigating the diagnostic accuracy of IVIM-DWI in lung lesions published through December 2020 were searched. The standardized mean differences (SMDs) of the apparent diffusion coefficient (ADC), tissue diffusivity (D), pseudo-diffusivity (D*), and perfusion fraction (f) were calculated. The sensitivity, specificity, area under the curve (AUC), publication bias, and heterogeneity were then summarized, and the source of heterogeneity and the reliability of combined results were explored by meta-regression and sensitivity analysis.ResultsA total of 16 studies including 714 malignant and 355 benign lesions were included. Significantly lower ADC, D, and f values were found in malignant pulmonary lesions compared to those in benign lesions. The D value showed the best diagnostic performance (sensitivity = 0.90, specificity = 0.71, AUC = 0.91), followed by ADC (sensitivity = 0.84, specificity = 0.75, AUC = 0.88), f (sensitivity = 0.70, specificity = 0.62, AUC = 0.71), and D* (sensitivity = 0.67, specificity = 0.61, AUC = 0.67). There was an inconspicuous publication bias in ADC, D, D* and f values, moderate heterogeneity in ADC, and high heterogeneity in D, D*, and f values. Subgroup analysis suggested that both ADC and D values had a significant higher sensitivity in “nodules or masses” than that in “nodules.”ConclusionsThe parameters derived from IVIM-DWI, especially the D value, could further improve the differential diagnosis between malignant and benign solitary pulmonary nodules and masses.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/#myprospero, identifier: CRD42021226664 |
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institution | Directory Open Access Journal |
issn | 2296-875X |
language | English |
last_indexed | 2024-04-13T09:39:39Z |
publishDate | 2022-06-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Surgery |
spelling | doaj.art-2dd96622370c4464a6dd2c314022fec62022-12-22T02:51:58ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-06-01910.3389/fsurg.2022.817443817443Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysisYirong Chen0Yirong Chen1Qijia Han2Zhiwei Huang3Zhiwei Huang4Mo Lyu5Mo Lyu6Zhu Ai7Yuying Liang8Haowen Yan9Mengzhu Wang10Zhiming Xiang11Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, ChinaDepartment of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, ChinaGraduate School, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, ChinaDepartment of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, ChinaSchool of Life Sciences, South China Normal University, Guangzhou, ChinaDepartment of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, ChinaDepartment of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, ChinaDepartment of Oncology, Guangzhou Panyu Central Hospital, Guangzhou, ChinaDepartment of MR Scientific Marketing, Siemens Healthineers, Guangzhou, ChinaDepartment of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, ChinaPurposeThis study aims to evaluate the accuracy of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in distinguishing malignant and benign solitary pulmonary nodules and masses.MethodsStudies investigating the diagnostic accuracy of IVIM-DWI in lung lesions published through December 2020 were searched. The standardized mean differences (SMDs) of the apparent diffusion coefficient (ADC), tissue diffusivity (D), pseudo-diffusivity (D*), and perfusion fraction (f) were calculated. The sensitivity, specificity, area under the curve (AUC), publication bias, and heterogeneity were then summarized, and the source of heterogeneity and the reliability of combined results were explored by meta-regression and sensitivity analysis.ResultsA total of 16 studies including 714 malignant and 355 benign lesions were included. Significantly lower ADC, D, and f values were found in malignant pulmonary lesions compared to those in benign lesions. The D value showed the best diagnostic performance (sensitivity = 0.90, specificity = 0.71, AUC = 0.91), followed by ADC (sensitivity = 0.84, specificity = 0.75, AUC = 0.88), f (sensitivity = 0.70, specificity = 0.62, AUC = 0.71), and D* (sensitivity = 0.67, specificity = 0.61, AUC = 0.67). There was an inconspicuous publication bias in ADC, D, D* and f values, moderate heterogeneity in ADC, and high heterogeneity in D, D*, and f values. Subgroup analysis suggested that both ADC and D values had a significant higher sensitivity in “nodules or masses” than that in “nodules.”ConclusionsThe parameters derived from IVIM-DWI, especially the D value, could further improve the differential diagnosis between malignant and benign solitary pulmonary nodules and masses.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/#myprospero, identifier: CRD42021226664https://www.frontiersin.org/articles/10.3389/fsurg.2022.817443/fullIVIM-DWImagnetic resonance imagingdifferential diagnosislung nodulesmeta-analysis |
spellingShingle | Yirong Chen Yirong Chen Qijia Han Zhiwei Huang Zhiwei Huang Mo Lyu Mo Lyu Zhu Ai Yuying Liang Haowen Yan Mengzhu Wang Zhiming Xiang Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis Frontiers in Surgery IVIM-DWI magnetic resonance imaging differential diagnosis lung nodules meta-analysis |
title | Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis |
title_full | Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis |
title_fullStr | Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis |
title_full_unstemmed | Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis |
title_short | Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis |
title_sort | value of ivim in differential diagnoses between benign and malignant solitary lung nodules and masses a meta analysis |
topic | IVIM-DWI magnetic resonance imaging differential diagnosis lung nodules meta-analysis |
url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.817443/full |
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