Comorbidities prolonged viral shedding of patients infected with SARS-CoV-2 omicron variant in Shanghai: A multi-center, retrospective, observational study
Background: As the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surges amid the coronavirus disease 2019 (COVID-19) pandemic, there is limited comorbidities data associated with viral shedding time (VST). We aimed to investigate the effect of comorbidities on VST i...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122003422 |
| _version_ | 1828065320043020288 |
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| author | Lei Pei Ying Chen Xiangtao Zheng Fangchen Gong Wenbin Liu Jingsheng Lin Ruizhi Zheng Zhitao Yang Yufang Bi Erzhen Chen |
| author_facet | Lei Pei Ying Chen Xiangtao Zheng Fangchen Gong Wenbin Liu Jingsheng Lin Ruizhi Zheng Zhitao Yang Yufang Bi Erzhen Chen |
| author_sort | Lei Pei |
| collection | DOAJ |
| description | Background: As the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surges amid the coronavirus disease 2019 (COVID-19) pandemic, there is limited comorbidities data associated with viral shedding time (VST). We aimed to investigate the effect of comorbidities on VST in asymptomatic and mild patients with omicron. Methods: A multi-center, retrospective, observational study was conducted from March 12, 2022 to May 24, 2022 in Shanghai. The analysis was adjusted for patients’ baseline demographic, using log-rank test and logistic regression model. Results: The study enrolled 198,262 subjects. The median duration of viral shedding time (VST) was 8.29 days. The number of cumulative viral shedding events was significantly lower in the chronic obstructive pulmonary disease (COPD), hyperlipidemia, diabetes, urinary system disease, and cardiocerebrovascular disease than in the no corresponding comorbidities group. Patients with comorbidities had a lower incidence of viral shedding, and the most significant independent risk factor is COPD (aOR 1.78, 95% CI: 1.53–2.08, p < 0.001). Across different age ranges, the comorbidities affecting viral shedding also differ, with the greatest risk factors for viral shedding being hyperlipidemia (aOR 2.23, 95% CI: 1.50–3.31, p < 0.001) and COPD (aOR 1.85, 95% CI: 1.50–2.28, p < 0.001) between ages of 18–39 and 40–64, and thyroid dysfunction (aOR 2.36, 95% CI: 1.60–3.47, p < 0.001) above age 64. Conclusions: Omicron-infected patients with comorbidities might prolong the VST. The independent risk factors also differ across age ranges, suggesting that providing targeted effective prevention and control guidance and allocating appropriate resources to different populations should be a crucial strategy. |
| first_indexed | 2024-04-10T23:13:07Z |
| format | Article |
| id | doaj.art-2dda2101b3754248b7e8f7d2d9b5332b |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-10T23:13:07Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-2dda2101b3754248b7e8f7d2d9b5332b2023-01-13T04:15:57ZengElsevierJournal of Infection and Public Health1876-03412023-02-01162182189Comorbidities prolonged viral shedding of patients infected with SARS-CoV-2 omicron variant in Shanghai: A multi-center, retrospective, observational studyLei Pei0Ying Chen1Xiangtao Zheng2Fangchen Gong3Wenbin Liu4Jingsheng Lin5Ruizhi Zheng6Zhitao Yang7Yufang Bi8Erzhen Chen9Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Disciplinary Development and Planning, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Ruijin No. 2 Road, Huangpu District, Shanghai 200025, China.Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Ruijin No. 2 Road, Huangpu District, Shanghai 200025, China.Background: As the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surges amid the coronavirus disease 2019 (COVID-19) pandemic, there is limited comorbidities data associated with viral shedding time (VST). We aimed to investigate the effect of comorbidities on VST in asymptomatic and mild patients with omicron. Methods: A multi-center, retrospective, observational study was conducted from March 12, 2022 to May 24, 2022 in Shanghai. The analysis was adjusted for patients’ baseline demographic, using log-rank test and logistic regression model. Results: The study enrolled 198,262 subjects. The median duration of viral shedding time (VST) was 8.29 days. The number of cumulative viral shedding events was significantly lower in the chronic obstructive pulmonary disease (COPD), hyperlipidemia, diabetes, urinary system disease, and cardiocerebrovascular disease than in the no corresponding comorbidities group. Patients with comorbidities had a lower incidence of viral shedding, and the most significant independent risk factor is COPD (aOR 1.78, 95% CI: 1.53–2.08, p < 0.001). Across different age ranges, the comorbidities affecting viral shedding also differ, with the greatest risk factors for viral shedding being hyperlipidemia (aOR 2.23, 95% CI: 1.50–3.31, p < 0.001) and COPD (aOR 1.85, 95% CI: 1.50–2.28, p < 0.001) between ages of 18–39 and 40–64, and thyroid dysfunction (aOR 2.36, 95% CI: 1.60–3.47, p < 0.001) above age 64. Conclusions: Omicron-infected patients with comorbidities might prolong the VST. The independent risk factors also differ across age ranges, suggesting that providing targeted effective prevention and control guidance and allocating appropriate resources to different populations should be a crucial strategy.http://www.sciencedirect.com/science/article/pii/S1876034122003422COVID-19SARS-CoV-2OmicronComorbidityViral shedding time |
| spellingShingle | Lei Pei Ying Chen Xiangtao Zheng Fangchen Gong Wenbin Liu Jingsheng Lin Ruizhi Zheng Zhitao Yang Yufang Bi Erzhen Chen Comorbidities prolonged viral shedding of patients infected with SARS-CoV-2 omicron variant in Shanghai: A multi-center, retrospective, observational study Journal of Infection and Public Health COVID-19 SARS-CoV-2 Omicron Comorbidity Viral shedding time |
| title | Comorbidities prolonged viral shedding of patients infected with SARS-CoV-2 omicron variant in Shanghai: A multi-center, retrospective, observational study |
| title_full | Comorbidities prolonged viral shedding of patients infected with SARS-CoV-2 omicron variant in Shanghai: A multi-center, retrospective, observational study |
| title_fullStr | Comorbidities prolonged viral shedding of patients infected with SARS-CoV-2 omicron variant in Shanghai: A multi-center, retrospective, observational study |
| title_full_unstemmed | Comorbidities prolonged viral shedding of patients infected with SARS-CoV-2 omicron variant in Shanghai: A multi-center, retrospective, observational study |
| title_short | Comorbidities prolonged viral shedding of patients infected with SARS-CoV-2 omicron variant in Shanghai: A multi-center, retrospective, observational study |
| title_sort | comorbidities prolonged viral shedding of patients infected with sars cov 2 omicron variant in shanghai a multi center retrospective observational study |
| topic | COVID-19 SARS-CoV-2 Omicron Comorbidity Viral shedding time |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122003422 |
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