SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a review
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a constellation of dermatological and osteoarticular symptoms. The pathogenesis of SAPHO is unknown, but infectious, genetic, immunological and environmental factors may play a role. SAPHO is classified along two different sp...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2020-07-01
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| Series: | Advances in Dermatology and Allergology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/SAPHO-syndrome-pathogenesis-clinical-presentation-r-nimaging-comorbidities-and-treatment-a-review,7,41354,1,1.html |
| _version_ | 1811183030457335808 |
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| author | Hanna Przepiera-Będzak Marek Brzosko |
| author_facet | Hanna Przepiera-Będzak Marek Brzosko |
| author_sort | Hanna Przepiera-Będzak |
| collection | DOAJ |
| description | Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a constellation of dermatological and osteoarticular symptoms. The pathogenesis of SAPHO is unknown, but infectious, genetic, immunological and environmental factors may play a role. SAPHO is classified along two different spectrums: pustulo-psoriatic hyperostotic spondyloarthritis and chronic recurrent multifocal osteomyelitis. The typical skin lesions are palmoplantar pustulosis and acne. The sign of arthritis is involvement of the anterior chest wall, most often the sternoclavicular joints. There are no standard treatment recommendations, but nonsteroidal anti-inflammatory drugs, sulfasalazine, methotrexate, antibiotics and biological drugs can be considered. |
| first_indexed | 2024-04-11T09:40:50Z |
| format | Article |
| id | doaj.art-2ddb790231724d2b80e52bec5a32c908 |
| institution | Directory Open Access Journal |
| issn | 1642-395X 2299-0046 |
| language | English |
| last_indexed | 2024-04-11T09:40:50Z |
| publishDate | 2020-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Advances in Dermatology and Allergology |
| spelling | doaj.art-2ddb790231724d2b80e52bec5a32c9082022-12-22T04:31:17ZengTermedia Publishing HouseAdvances in Dermatology and Allergology1642-395X2299-00462020-07-0138693794210.5114/ada.2020.9739441354SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a reviewHanna Przepiera-BędzakMarek BrzoskoSynovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a constellation of dermatological and osteoarticular symptoms. The pathogenesis of SAPHO is unknown, but infectious, genetic, immunological and environmental factors may play a role. SAPHO is classified along two different spectrums: pustulo-psoriatic hyperostotic spondyloarthritis and chronic recurrent multifocal osteomyelitis. The typical skin lesions are palmoplantar pustulosis and acne. The sign of arthritis is involvement of the anterior chest wall, most often the sternoclavicular joints. There are no standard treatment recommendations, but nonsteroidal anti-inflammatory drugs, sulfasalazine, methotrexate, antibiotics and biological drugs can be considered.https://www.termedia.pl/SAPHO-syndrome-pathogenesis-clinical-presentation-r-nimaging-comorbidities-and-treatment-a-review,7,41354,1,1.htmlsynovitis acne pustulosis hyperostosis and osteitis (sapho) pathogenesis clinical presentation imaging comorbidities treatment. |
| spellingShingle | Hanna Przepiera-Będzak Marek Brzosko SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a review Advances in Dermatology and Allergology synovitis acne pustulosis hyperostosis and osteitis (sapho) pathogenesis clinical presentation imaging comorbidities treatment. |
| title | SAPHO syndrome: pathogenesis, clinical presentation,
imaging, comorbidities and treatment: a review |
| title_full | SAPHO syndrome: pathogenesis, clinical presentation,
imaging, comorbidities and treatment: a review |
| title_fullStr | SAPHO syndrome: pathogenesis, clinical presentation,
imaging, comorbidities and treatment: a review |
| title_full_unstemmed | SAPHO syndrome: pathogenesis, clinical presentation,
imaging, comorbidities and treatment: a review |
| title_short | SAPHO syndrome: pathogenesis, clinical presentation,
imaging, comorbidities and treatment: a review |
| title_sort | sapho syndrome pathogenesis clinical presentation imaging comorbidities and treatment a review |
| topic | synovitis acne pustulosis hyperostosis and osteitis (sapho) pathogenesis clinical presentation imaging comorbidities treatment. |
| url | https://www.termedia.pl/SAPHO-syndrome-pathogenesis-clinical-presentation-r-nimaging-comorbidities-and-treatment-a-review,7,41354,1,1.html |
| work_keys_str_mv | AT hannaprzepierabedzak saphosyndromepathogenesisclinicalpresentationimagingcomorbiditiesandtreatmentareview AT marekbrzosko saphosyndromepathogenesisclinicalpresentationimagingcomorbiditiesandtreatmentareview |