Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing
Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possi...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.935371/full |
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| author | Li Xia Sara Ripley Zhenhua Jiang Xue Yin Zhiping Yu Steve J. Aiken Jian Wang Jian Wang |
| author_facet | Li Xia Sara Ripley Zhenhua Jiang Xue Yin Zhiping Yu Steve J. Aiken Jian Wang Jian Wang |
| author_sort | Li Xia |
| collection | DOAJ |
| description | Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possible since noise exposure used in laboratory animals is generally different from what is experienced by human subjects in real life. An additional problem is a lack of morphological data and reliable functional methods to quantify loss of afferent synapses in humans. Based on evidence for disproportionate synaptic loss for auditory nerve fibers (ANFs) with low spontaneous rates (LSR), coding-in-noise deficits (CIND) have been speculated to be the major difficulty associated with NIS without PTS. However, no robust evidence for this is available in humans or animals. This has led to a re-examination of the role of LSR ANFs in signal coding in high-level noise. The fluctuation profile model has been proposed to support a role for high-SR ANFs in the coding of high-level noise in combination with efferent control of cochlear gain. This study aimed to induce NIS by a low-level, intermittent noise exposure mimicking what is experienced in human life and examined the impact of the NIS on temporal processing under masking. It also evaluated the role of temporal fluctuation in evoking efferent feedback and the effects of NIS on this feedback. |
| first_indexed | 2024-12-11T05:01:08Z |
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| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T05:01:08Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-2ddf8d91543f4d958fc80c1a3a83cd792022-12-22T01:20:09ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-07-011610.3389/fnins.2022.935371935371Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal ProcessingLi Xia0Sara Ripley1Zhenhua Jiang2Xue Yin3Zhiping Yu4Steve J. Aiken5Jian Wang6Jian Wang7Department of Otolaryngology-Head and Neck Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaSchool of Communication Sciences and Disorders, Dalhousie University, Halifax, NS, CanadaDepartment of Otolaryngology-Head and Neck Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaSchool of Communication Sciences and Disorders, Dalhousie University, Halifax, NS, CanadaSchool of Communication Sciences and Disorders, Dalhousie University, Halifax, NS, CanadaDepartment of Otolaryngology-Head and Neck Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaSchool of Communication Sciences and Disorders, Dalhousie University, Halifax, NS, CanadaNoise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possible since noise exposure used in laboratory animals is generally different from what is experienced by human subjects in real life. An additional problem is a lack of morphological data and reliable functional methods to quantify loss of afferent synapses in humans. Based on evidence for disproportionate synaptic loss for auditory nerve fibers (ANFs) with low spontaneous rates (LSR), coding-in-noise deficits (CIND) have been speculated to be the major difficulty associated with NIS without PTS. However, no robust evidence for this is available in humans or animals. This has led to a re-examination of the role of LSR ANFs in signal coding in high-level noise. The fluctuation profile model has been proposed to support a role for high-SR ANFs in the coding of high-level noise in combination with efferent control of cochlear gain. This study aimed to induce NIS by a low-level, intermittent noise exposure mimicking what is experienced in human life and examined the impact of the NIS on temporal processing under masking. It also evaluated the role of temporal fluctuation in evoking efferent feedback and the effects of NIS on this feedback.https://www.frontiersin.org/articles/10.3389/fnins.2022.935371/fulltemporal processingcoding-in-noise deficitcochlear efferentfluctuation profileGuinea pigsnoise-induced synaptopathy |
| spellingShingle | Li Xia Sara Ripley Zhenhua Jiang Xue Yin Zhiping Yu Steve J. Aiken Jian Wang Jian Wang Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing Frontiers in Neuroscience temporal processing coding-in-noise deficit cochlear efferent fluctuation profile Guinea pigs noise-induced synaptopathy |
| title | Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing |
| title_full | Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing |
| title_fullStr | Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing |
| title_full_unstemmed | Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing |
| title_short | Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing |
| title_sort | synaptopathy in guinea pigs induced by noise mimicking human experience and associated changes in auditory signal processing |
| topic | temporal processing coding-in-noise deficit cochlear efferent fluctuation profile Guinea pigs noise-induced synaptopathy |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.935371/full |
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