Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing

Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing

Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possi...

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Bibliographic Details
Main Authors: Li Xia, Sara Ripley, Zhenhua Jiang, Xue Yin, Zhiping Yu, Steve J. Aiken, Jian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Neuroscience
Subjects:
temporal processing
coding-in-noise deficit
cochlear efferent
fluctuation profile
Guinea pigs
noise-induced synaptopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.935371/full

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