The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models
Inflammatory bowel disease (IBD), including Crohn′s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder characterized by alternating phases of clinical relapse and remission. The etiology of IBD remains largely unknown, although a combination of patient′s immune response, ge...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=1;spage=3;epage=17;aulast=Balmus |
| _version_ | 1819125299884851200 |
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| author | Ioana Miruna Balmus Alin Ciobica Anca Trifan Carol Stanciu |
| author_facet | Ioana Miruna Balmus Alin Ciobica Anca Trifan Carol Stanciu |
| author_sort | Ioana Miruna Balmus |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), including Crohn′s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder characterized by alternating phases of clinical relapse and remission. The etiology of IBD remains largely unknown, although a combination of patient′s immune response, genetics, microbiome, and environment plays an important role in disturbing intestinal homeostasis, leading to development and perpetuation of the inflammatory cascade in IBD. As chronic intestinal inflammation is associated with the formation of reactive oxygen and reactive nitrogen species (ROS and RNS), oxidative and nitrosative stress has been proposed as one of the major contributing factor in the IBD development. Substantial evidence suggests that IBD is associated with an imbalance between increased ROS and decreased antioxidant activity, which may explain, at least in part, many of the clinical pathophysiological features of both CD and UC patients. Hereby, we review the presently known oxidant and antioxidant mechanisms involved in IBD-specific events, the animal models used to determine these specific features, and also the antioxidant therapies proposed in IBD patients. |
| first_indexed | 2024-12-22T07:37:56Z |
| format | Article |
| id | doaj.art-2de30e609aa8414b95c7c6bf4851081f |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-22T07:37:56Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-2de30e609aa8414b95c7c6bf4851081f2022-12-21T18:33:48ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492016-01-0122131710.4103/1319-3767.173753The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal modelsIoana Miruna BalmusAlin CiobicaAnca TrifanCarol StanciuInflammatory bowel disease (IBD), including Crohn′s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder characterized by alternating phases of clinical relapse and remission. The etiology of IBD remains largely unknown, although a combination of patient′s immune response, genetics, microbiome, and environment plays an important role in disturbing intestinal homeostasis, leading to development and perpetuation of the inflammatory cascade in IBD. As chronic intestinal inflammation is associated with the formation of reactive oxygen and reactive nitrogen species (ROS and RNS), oxidative and nitrosative stress has been proposed as one of the major contributing factor in the IBD development. Substantial evidence suggests that IBD is associated with an imbalance between increased ROS and decreased antioxidant activity, which may explain, at least in part, many of the clinical pathophysiological features of both CD and UC patients. Hereby, we review the presently known oxidant and antioxidant mechanisms involved in IBD-specific events, the animal models used to determine these specific features, and also the antioxidant therapies proposed in IBD patients.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=1;spage=3;epage=17;aulast=BalmusAnimal modelsantioxidantsCrohn′s diseaselipid peroxidationreactive oxygen speciesulcerative colitis |
| spellingShingle | Ioana Miruna Balmus Alin Ciobica Anca Trifan Carol Stanciu The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models The Saudi Journal of Gastroenterology Animal models antioxidants Crohn′s disease lipid peroxidation reactive oxygen species ulcerative colitis |
| title | The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models |
| title_full | The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models |
| title_fullStr | The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models |
| title_full_unstemmed | The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models |
| title_short | The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models |
| title_sort | implications of oxidative stress and antioxidant therapies in inflammatory bowel disease clinical aspects and animal models |
| topic | Animal models antioxidants Crohn′s disease lipid peroxidation reactive oxygen species ulcerative colitis |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=1;spage=3;epage=17;aulast=Balmus |
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