Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats

Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats

Background: Evidence is accruing to suggest that microbiota-gut-brain signalling plays a regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling human sleep apnoea, affects gut microbiota composition and elicits cardiorespiratory morbidity. We investigated if t...

Full description

Bibliographic Details
Main Authors: Karen M. O'Connor, Eric F. Lucking, Thomaz F.S. Bastiaanssen, Veronica L. Peterson, Fiona Crispie, Paul D. Cotter, Gerard Clarke, John F. Cryan, Ken D. O'Halloran
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:EBioMedicine
Subjects:
Chronic intermittent hypoxia
Prebiotics
Apnoea
Hypertension
Autonomic dysfunction
Neurochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303443

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420303443

Similar Items