Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats

Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats

Background: Evidence is accruing to suggest that microbiota-gut-brain signalling plays a regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling human sleep apnoea, affects gut microbiota composition and elicits cardiorespiratory morbidity. We investigated if t...

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Bibliographic Details
Main Authors: Karen M. O'Connor, Eric F. Lucking, Thomaz F.S. Bastiaanssen, Veronica L. Peterson, Fiona Crispie, Paul D. Cotter, Gerard Clarke, John F. Cryan, Ken D. O'Halloran
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:EBioMedicine
Subjects:
Chronic intermittent hypoxia
Prebiotics
Apnoea
Hypertension
Autonomic dysfunction
Neurochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303443

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