The rate of epigenetic drift scales with maximum lifespan across mammals
Abstract Epigenetic drift or “disorder” increases across the mouse lifespan and is suggested to underlie epigenetic clock signals. While the role of epigenetic drift in determining maximum lifespan across species has been debated, robust tests of this hypothesis are lacking. Here, we test if epigene...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-43417-6 |
| _version_ | 1797452089688850432 |
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| author | Emily M. Bertucci-Richter Benjamin B. Parrott |
| author_facet | Emily M. Bertucci-Richter Benjamin B. Parrott |
| author_sort | Emily M. Bertucci-Richter |
| collection | DOAJ |
| description | Abstract Epigenetic drift or “disorder” increases across the mouse lifespan and is suggested to underlie epigenetic clock signals. While the role of epigenetic drift in determining maximum lifespan across species has been debated, robust tests of this hypothesis are lacking. Here, we test if epigenetic disorder at various levels of genomic resolution explains maximum lifespan across four mammal species. We show that epigenetic disorder increases with age in all species and at all levels of genomic resolution tested. The rate of disorder accumulation occurs faster in shorter lived species and corresponds to species adjusted maximum lifespan. While the density of cytosine-phosphate-guanine dinucleotides (“CpGs”) is negatively associated with the rate of age-associated disorder accumulation, it does not fully explain differences across species. Our findings support the hypothesis that the rate of epigenetic drift explains maximum lifespan and provide partial support for the hypothesis that CpG density buffers against epigenetic drift. |
| first_indexed | 2024-03-09T15:03:44Z |
| format | Article |
| id | doaj.art-2de6a7075ab4408f86c3a33ecff5b857 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-09T15:03:44Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2de6a7075ab4408f86c3a33ecff5b8572023-11-26T13:45:04ZengNature PortfolioNature Communications2041-17232023-11-011411810.1038/s41467-023-43417-6The rate of epigenetic drift scales with maximum lifespan across mammalsEmily M. Bertucci-Richter0Benjamin B. Parrott1Savannah River Ecology Laboratory, University of GeorgiaSavannah River Ecology Laboratory, University of GeorgiaAbstract Epigenetic drift or “disorder” increases across the mouse lifespan and is suggested to underlie epigenetic clock signals. While the role of epigenetic drift in determining maximum lifespan across species has been debated, robust tests of this hypothesis are lacking. Here, we test if epigenetic disorder at various levels of genomic resolution explains maximum lifespan across four mammal species. We show that epigenetic disorder increases with age in all species and at all levels of genomic resolution tested. The rate of disorder accumulation occurs faster in shorter lived species and corresponds to species adjusted maximum lifespan. While the density of cytosine-phosphate-guanine dinucleotides (“CpGs”) is negatively associated with the rate of age-associated disorder accumulation, it does not fully explain differences across species. Our findings support the hypothesis that the rate of epigenetic drift explains maximum lifespan and provide partial support for the hypothesis that CpG density buffers against epigenetic drift.https://doi.org/10.1038/s41467-023-43417-6 |
| spellingShingle | Emily M. Bertucci-Richter Benjamin B. Parrott The rate of epigenetic drift scales with maximum lifespan across mammals Nature Communications |
| title | The rate of epigenetic drift scales with maximum lifespan across mammals |
| title_full | The rate of epigenetic drift scales with maximum lifespan across mammals |
| title_fullStr | The rate of epigenetic drift scales with maximum lifespan across mammals |
| title_full_unstemmed | The rate of epigenetic drift scales with maximum lifespan across mammals |
| title_short | The rate of epigenetic drift scales with maximum lifespan across mammals |
| title_sort | rate of epigenetic drift scales with maximum lifespan across mammals |
| url | https://doi.org/10.1038/s41467-023-43417-6 |
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