Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on Prognosis
Objective:The aim was to investigate the effect of primary tumor resection (PTR) on survival in metastatic breast cancer patients and to assess the power of the neutrophil-to-lymphocyte ratio (NLR) regarding the prediction of prognosis in this patient group.Materials and Methods:Female patients diag...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-10-01
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| Series: | European Journal of Breast Health |
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http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/effects-of-primary-tumor-resection-on-metastatic-b/49059
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| _version_ | 1797924170911186944 |
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| author | Yaşar Çöpelci Umut Rıza Gündüz Bülent Dinç Nurhan Haluk Belen Şeyda Gündüz |
| author_facet | Yaşar Çöpelci Umut Rıza Gündüz Bülent Dinç Nurhan Haluk Belen Şeyda Gündüz |
| author_sort | Yaşar Çöpelci |
| collection | DOAJ |
| description | Objective:The aim was to investigate the effect of primary tumor resection (PTR) on survival in metastatic breast cancer patients and to assess the power of the neutrophil-to-lymphocyte ratio (NLR) regarding the prediction of prognosis in this patient group.Materials and Methods:Female patients diagnosed with and starting treatment for metastatic breast cancer from 2003 to 2016 in the general surgery and oncology clinics at a single center were retrospectively reviewed. Pre-treatment NLR value and survival situations were evaluated.Results:A total of 117 patients were enrolled. The disease-specific survival (DSS) of the patients was 41.4 months. When stratified into PTR and systemic treatment (ST) groups, there was no difference in the survival (p = 0.054); 43.5 months in the PTR group vs 30.7 months in the ST group. When hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative subgroups were analyzed, DSS was significantly longer (p = 0.02) in the PTR group (55.4 months) compared to the ST group (41.8 months). Finally, in patients with an NLR of <2.3, DSS was significantly longer (p = 0.03) in the PTR group (56.1 months) compared to the ST group (25.2 months).Conclusion:These results suggest that DSS can be increased with PTR in selected patients with a diagnosis of metastatic breast cancer. NLR may be useful in selecting patients for appropraite treatment modality. |
| first_indexed | 2024-04-10T14:57:21Z |
| format | Article |
| id | doaj.art-2de8013017e2485985ab4fbce50c8deb |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T14:57:21Z |
| publishDate | 2021-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-2de8013017e2485985ab4fbce50c8deb2023-02-15T16:07:17ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312021-10-0117432232710.4274/ejbh.galenos.2021.2021-3-213049054Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on PrognosisYaşar Çöpelci0Umut Rıza Gündüz1Bülent Dinç2Nurhan Haluk Belen3Şeyda Gündüz4 Department of General Surgery, University of Health Sciences Turkey, Erzurum Regional Training and Research Hospital, Erzurum, Turkey Department of General Surgery, University of Health Sciences Turkey, Antalya Training and Research Hospital, Antalya, Turkey Department of General Surgery, University of Health Sciences Turkey, Antalya Training and Research Hospital, Antalya, Turkey Department of General Surgery, University of Health Sciences Turkey, Antalya Training and Research Hospital, Antalya, Turkey Clinic of Medical Oncology, Memorial Antalya Hospital, Antalya, Turkey Objective:The aim was to investigate the effect of primary tumor resection (PTR) on survival in metastatic breast cancer patients and to assess the power of the neutrophil-to-lymphocyte ratio (NLR) regarding the prediction of prognosis in this patient group.Materials and Methods:Female patients diagnosed with and starting treatment for metastatic breast cancer from 2003 to 2016 in the general surgery and oncology clinics at a single center were retrospectively reviewed. Pre-treatment NLR value and survival situations were evaluated.Results:A total of 117 patients were enrolled. The disease-specific survival (DSS) of the patients was 41.4 months. When stratified into PTR and systemic treatment (ST) groups, there was no difference in the survival (p = 0.054); 43.5 months in the PTR group vs 30.7 months in the ST group. When hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative subgroups were analyzed, DSS was significantly longer (p = 0.02) in the PTR group (55.4 months) compared to the ST group (41.8 months). Finally, in patients with an NLR of <2.3, DSS was significantly longer (p = 0.03) in the PTR group (56.1 months) compared to the ST group (25.2 months).Conclusion:These results suggest that DSS can be increased with PTR in selected patients with a diagnosis of metastatic breast cancer. NLR may be useful in selecting patients for appropraite treatment modality. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/effects-of-primary-tumor-resection-on-metastatic-b/49059 metastatic breast cancerprimary tumor resectionneutrophil-to-lymphocyte ratiosurvival |
| spellingShingle | Yaşar Çöpelci Umut Rıza Gündüz Bülent Dinç Nurhan Haluk Belen Şeyda Gündüz Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on Prognosis European Journal of Breast Health metastatic breast cancer primary tumor resection neutrophil-to-lymphocyte ratio survival |
| title | Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on Prognosis |
| title_full | Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on Prognosis |
| title_fullStr | Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on Prognosis |
| title_full_unstemmed | Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on Prognosis |
| title_short | Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on Prognosis |
| title_sort | effects of primary tumor resection on metastatic breast cancer survival and the predictive power of neutrophil lymphocyte ratio on prognosis |
| topic | metastatic breast cancer primary tumor resection neutrophil-to-lymphocyte ratio survival |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/effects-of-primary-tumor-resection-on-metastatic-b/49059
|
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