Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed
Exosomes are nano-vesicles of endosomal origin inherited with characteristics of drug delivery and cargo loading. Exosomes offer a diverse range of opportunities that can be exploited in the treatment of various diseases post-functionalization. This membrane engineering is recently being used in the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.712588/full |
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| author | Alok Raghav Prashant Tripathi Brijesh Kumar Mishra Goo-Bo Jeong Shahid Banday Kirti Amresh Gautam Qazi Noorul Mateen Prem Singh Manish Singh Akhil Singla Jamal Ahmad |
| author_facet | Alok Raghav Prashant Tripathi Brijesh Kumar Mishra Goo-Bo Jeong Shahid Banday Kirti Amresh Gautam Qazi Noorul Mateen Prem Singh Manish Singh Akhil Singla Jamal Ahmad |
| author_sort | Alok Raghav |
| collection | DOAJ |
| description | Exosomes are nano-vesicles of endosomal origin inherited with characteristics of drug delivery and cargo loading. Exosomes offer a diverse range of opportunities that can be exploited in the treatment of various diseases post-functionalization. This membrane engineering is recently being used in the management of bacteria-associated diabetic foot ulcers (DFUs). Diabetes mellitus (DM) is among the most crippling disease of society with a large share of its imposing economic burden. DM in a chronic state is associated with the development of micro- and macrovascular complications. DFU is among the diabetic microvascular complications with the consequent occurrence of diabetic peripheral neuropathy. Mesenchymal stromal cell (MSC)-derived exosomes post-tailoring hold promise to accelerate the diabetic wound repair in DFU associated with bacterial inhabitant. These exosomes promote the antibacterial properties with regenerative activity by loading bioactive molecules like growth factors, nucleic acids, and proteins, and non-bioactive substances like antibiotics. Functionalization of MSC-derived exosomes is mediated by various physical, chemical, and biological processes that effectively load the desired cargo into the exosomes for targeted delivery at specific bacterial DFUs and wound. The present study focused on the application of the cargo-loaded exosomes in the treatment of DFU and also emphasizes the different approaches for loading the desired cargo/drug inside exosomes. However, more studies and clinical trials are needed in the domain to explore this membrane engineering. |
| first_indexed | 2024-12-22T11:01:10Z |
| format | Article |
| id | doaj.art-2de93b61d04242d1a00d3b947f3e7aae |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T11:01:10Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-2de93b61d04242d1a00d3b947f3e7aae2022-12-21T18:28:29ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-07-011210.3389/fmicb.2021.712588712588Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to BedAlok Raghav0Prashant Tripathi1Brijesh Kumar Mishra2Goo-Bo Jeong3Shahid Banday4Kirti Amresh Gautam5Qazi Noorul Mateen6Prem Singh7Manish Singh8Akhil Singla9Jamal Ahmad10Multidisciplinary Research Unit, Department of Health Research, MoHFW, GSVM Medical College, Kanpur, IndiaDepartment of Biochemistry, GSVM Medical College, Kanpur, IndiaDepartment of Endocrinology, UCMS, GTB Hospital, New Delhi, IndiaDepartment of Anatomy and Cell Biology, College of Medicine, Gachon University, Incheon, South KoreaDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, United StatesMultidisciplinary Research Unit, Department of Health Research, MoHFW, GSVM Medical College, Kanpur, IndiaDepartment of Biochemical Engineering, Indian Institute of Technology Delhi, New Delhi, IndiaDepartment of Medicine, GSVM Medical College, Kanpur, IndiaDepartment of Neurosurgery, GSVM Medical College, Kanpur, IndiaDepartment of Medicine, Maharishi Markandeshwar College and Hospital, Maharishi Markandeshwar University, Solan, India0Faculty of Medicine, Rajiv Gandhi Centre for Diabetes and Endocrinology, JN Medical College, Aligarh Muslim University, Aligarh, IndiaExosomes are nano-vesicles of endosomal origin inherited with characteristics of drug delivery and cargo loading. Exosomes offer a diverse range of opportunities that can be exploited in the treatment of various diseases post-functionalization. This membrane engineering is recently being used in the management of bacteria-associated diabetic foot ulcers (DFUs). Diabetes mellitus (DM) is among the most crippling disease of society with a large share of its imposing economic burden. DM in a chronic state is associated with the development of micro- and macrovascular complications. DFU is among the diabetic microvascular complications with the consequent occurrence of diabetic peripheral neuropathy. Mesenchymal stromal cell (MSC)-derived exosomes post-tailoring hold promise to accelerate the diabetic wound repair in DFU associated with bacterial inhabitant. These exosomes promote the antibacterial properties with regenerative activity by loading bioactive molecules like growth factors, nucleic acids, and proteins, and non-bioactive substances like antibiotics. Functionalization of MSC-derived exosomes is mediated by various physical, chemical, and biological processes that effectively load the desired cargo into the exosomes for targeted delivery at specific bacterial DFUs and wound. The present study focused on the application of the cargo-loaded exosomes in the treatment of DFU and also emphasizes the different approaches for loading the desired cargo/drug inside exosomes. However, more studies and clinical trials are needed in the domain to explore this membrane engineering.https://www.frontiersin.org/articles/10.3389/fmicb.2021.712588/fullexosomesdiabetes foot ulcersdiabetes mellituscustomized exosomesbacterial infection |
| spellingShingle | Alok Raghav Prashant Tripathi Brijesh Kumar Mishra Goo-Bo Jeong Shahid Banday Kirti Amresh Gautam Qazi Noorul Mateen Prem Singh Manish Singh Akhil Singla Jamal Ahmad Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed Frontiers in Microbiology exosomes diabetes foot ulcers diabetes mellitus customized exosomes bacterial infection |
| title | Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed |
| title_full | Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed |
| title_fullStr | Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed |
| title_full_unstemmed | Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed |
| title_short | Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed |
| title_sort | mesenchymal stromal cell derived tailored exosomes treat bacteria associated diabetes foot ulcers a customized approach from bench to bed |
| topic | exosomes diabetes foot ulcers diabetes mellitus customized exosomes bacterial infection |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.712588/full |
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