Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat
Background: Male reproductive dysfunction is a common health concern and can affect the quality of life. This study evaluated the curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat. Materials and Methods: Sixteen male Wistar r...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | International Journal of Medicine and Health Development |
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| Online Access: | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2020;volume=25;issue=1;spage=11;epage=15;aulast=Akpobasaha |
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| author | Seno Akpobasaha Joseph O Ezugworie Nto J Nto Uloaku A Nto-Ezimah |
| author_facet | Seno Akpobasaha Joseph O Ezugworie Nto J Nto Uloaku A Nto-Ezimah |
| author_sort | Seno Akpobasaha |
| collection | DOAJ |
| description | Background: Male reproductive dysfunction is a common health concern and can affect the quality of life. This study evaluated the curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat. Materials and Methods: Sixteen male Wistar rats were randomly divided into four groups of four rats each, labeled Groups A–D. Group A was the negative control, Group B (positive control) received 10 mg/kg body weight of flutamide. Groups C and D were given 10 mg/kg body weight of flutamide per day for 7 days and discontinued, they were treated with 100 and 300 mg/kg body weight of aqueous extract of B. dalzielii, respectively, from days 8 to 21. All administrations were carried out orally. Results: There was a dose-dependent increase in body weight, raised serum testosterone levels, and increased cellular proliferation following administration of B. dalzielii on flutamide-induced testicular toxicity. Conclusion: The result of this study suggests that the aqueous extract of the bark of B. dalzielii has a therapeutic effect on flutamide-induced testicular toxicity. |
| first_indexed | 2024-04-13T10:50:58Z |
| format | Article |
| id | doaj.art-2decca5cb34b494ab353af1ae57eb546 |
| institution | Directory Open Access Journal |
| issn | 2635-3695 |
| language | English |
| last_indexed | 2024-04-13T10:50:58Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Medicine and Health Development |
| spelling | doaj.art-2decca5cb34b494ab353af1ae57eb5462022-12-22T02:49:39ZengWolters Kluwer Medknow PublicationsInternational Journal of Medicine and Health Development2635-36952020-01-01251111510.4103/ijmh.IJMH_22_19Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar ratSeno AkpobasahaJoseph O EzugworieNto J NtoUloaku A Nto-EzimahBackground: Male reproductive dysfunction is a common health concern and can affect the quality of life. This study evaluated the curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat. Materials and Methods: Sixteen male Wistar rats were randomly divided into four groups of four rats each, labeled Groups A–D. Group A was the negative control, Group B (positive control) received 10 mg/kg body weight of flutamide. Groups C and D were given 10 mg/kg body weight of flutamide per day for 7 days and discontinued, they were treated with 100 and 300 mg/kg body weight of aqueous extract of B. dalzielii, respectively, from days 8 to 21. All administrations were carried out orally. Results: There was a dose-dependent increase in body weight, raised serum testosterone levels, and increased cellular proliferation following administration of B. dalzielii on flutamide-induced testicular toxicity. Conclusion: The result of this study suggests that the aqueous extract of the bark of B. dalzielii has a therapeutic effect on flutamide-induced testicular toxicity.http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2020;volume=25;issue=1;spage=11;epage=15;aulast=Akpobasahaaphrodisiacboswellia dalzieliiflutamidemale reproductive dysfunctiontestes |
| spellingShingle | Seno Akpobasaha Joseph O Ezugworie Nto J Nto Uloaku A Nto-Ezimah Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat International Journal of Medicine and Health Development aphrodisiac boswellia dalzielii flutamide male reproductive dysfunction testes |
| title | Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat |
| title_full | Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat |
| title_fullStr | Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat |
| title_full_unstemmed | Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat |
| title_short | Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat |
| title_sort | curative effect of aqueous extract of the bark of boswellia dalzielii on flutamide induced testicular toxicity in wistar rat |
| topic | aphrodisiac boswellia dalzielii flutamide male reproductive dysfunction testes |
| url | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2020;volume=25;issue=1;spage=11;epage=15;aulast=Akpobasaha |
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