Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde
Abstract In November 2015, cases of Zika virus infection were recorded in Cabo Verde (Africa), originating from Brazil. The outbreak subsided after seven months with 7580 suspected cases. We performed a serological survey (n = 431) in Praia, the capital city, 3 months after transmission ceased. Seru...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16115-4 |
| _version_ | 1818518304416858112 |
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| author | Daniel Ward Ana Rita Gomes Kevin K. A. Tetteh Nuno Sepúlveda Lara Ferrero Gomez Susana Campino Taane G. Clark |
| author_facet | Daniel Ward Ana Rita Gomes Kevin K. A. Tetteh Nuno Sepúlveda Lara Ferrero Gomez Susana Campino Taane G. Clark |
| author_sort | Daniel Ward |
| collection | DOAJ |
| description | Abstract In November 2015, cases of Zika virus infection were recorded in Cabo Verde (Africa), originating from Brazil. The outbreak subsided after seven months with 7580 suspected cases. We performed a serological survey (n = 431) in Praia, the capital city, 3 months after transmission ceased. Serum samples were screened for arbovirus antibodies using ELISA techniques and revealed seroconverted individuals with Zika (10.9%), dengue (1–4) (12.5%), yellow fever (0.2%) and chikungunya (2.6%) infections. Zika seropositivity was predominantly observed amongst females (70%). Using a logistic model, risk factors for increased odds of Zika seropositivity included age, self-reported Zika infection, and dengue seropositivity. Serological data from Zika and dengue virus assays were strongly correlated (Spearman’s rs = 0.80), which reduced when using a double antigen binding ELISA (Spearman’s rs = 0.54). Overall, our work improves an understanding of how Zika and other arboviruses have spread throughout the Cabo Verde population. It also demonstrates the utility of serological assay formats for outbreak investigations. |
| first_indexed | 2024-12-11T01:08:30Z |
| format | Article |
| id | doaj.art-2dee848621784a0e8c9ab964507c75f2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-11T01:08:30Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2dee848621784a0e8c9ab964507c75f22022-12-22T01:26:06ZengNature PortfolioScientific Reports2045-23222022-07-011211810.1038/s41598-022-16115-4Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo VerdeDaniel Ward0Ana Rita Gomes1Kevin K. A. Tetteh2Nuno Sepúlveda3Lara Ferrero Gomez4Susana Campino5Taane G. Clark6Department of Infection Biology, London School of Hygiene and Tropical MedicineUniversité de MontpellierDepartment of Infection Biology, London School of Hygiene and Tropical MedicineWarsaw University of TechnologyUniversidade Jean Piaget (UniPiaget)Department of Infection Biology, London School of Hygiene and Tropical MedicineDepartment of Infection Biology, London School of Hygiene and Tropical MedicineAbstract In November 2015, cases of Zika virus infection were recorded in Cabo Verde (Africa), originating from Brazil. The outbreak subsided after seven months with 7580 suspected cases. We performed a serological survey (n = 431) in Praia, the capital city, 3 months after transmission ceased. Serum samples were screened for arbovirus antibodies using ELISA techniques and revealed seroconverted individuals with Zika (10.9%), dengue (1–4) (12.5%), yellow fever (0.2%) and chikungunya (2.6%) infections. Zika seropositivity was predominantly observed amongst females (70%). Using a logistic model, risk factors for increased odds of Zika seropositivity included age, self-reported Zika infection, and dengue seropositivity. Serological data from Zika and dengue virus assays were strongly correlated (Spearman’s rs = 0.80), which reduced when using a double antigen binding ELISA (Spearman’s rs = 0.54). Overall, our work improves an understanding of how Zika and other arboviruses have spread throughout the Cabo Verde population. It also demonstrates the utility of serological assay formats for outbreak investigations.https://doi.org/10.1038/s41598-022-16115-4 |
| spellingShingle | Daniel Ward Ana Rita Gomes Kevin K. A. Tetteh Nuno Sepúlveda Lara Ferrero Gomez Susana Campino Taane G. Clark Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde Scientific Reports |
| title | Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde |
| title_full | Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde |
| title_fullStr | Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde |
| title_full_unstemmed | Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde |
| title_short | Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde |
| title_sort | sero epidemiological study of arbovirus infection following the 2015 2016 zika virus outbreak in cabo verde |
| url | https://doi.org/10.1038/s41598-022-16115-4 |
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