Very high frequency of fragility fractures associated with high-dose glucocorticoids in postmenopausal women: A retrospective study
Purpose To evaluate the incidence of fragility fractures associated with high-dose glucocorticoid therapy in patients with systemic rheumatic disease. Methods: A retrospective study of patients who were treated with high-dose prednisolone (>0.8 mg/kg) for systemic rheumatic disease at Kobe Univer...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-06-01
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| Series: | Bone Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187216300511 |
| _version_ | 1831738916081762304 |
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| author | Goichi Kageyama Takaichi Okano Yuzuru Yamamoto Keisuke Nishimura Daisuke Sugiyama Jun Saegusa Goh Tsuji Shunichi Kumagai Akio Morinobu |
| author_facet | Goichi Kageyama Takaichi Okano Yuzuru Yamamoto Keisuke Nishimura Daisuke Sugiyama Jun Saegusa Goh Tsuji Shunichi Kumagai Akio Morinobu |
| author_sort | Goichi Kageyama |
| collection | DOAJ |
| description | Purpose
To evaluate the incidence of fragility fractures associated with high-dose glucocorticoid therapy in patients with systemic rheumatic disease.
Methods: A retrospective study of patients who were treated with high-dose prednisolone (>0.8 mg/kg) for systemic rheumatic disease at Kobe University Hospital from April 1988 to March 2012. The primary outcome was a major osteoporotic fracture (defined as a clinical vertebral, hip, forearm, or proximal humerus fracture) after high-dose glucocorticoid therapy. For postmenopausal women and men over 40 of age, the patient's fracture risk at the beginning of high-dose glucocorticoid therapy was assessed by the World Health Organization's Fracture Risk Assessment Tool (FRAX®).
Results
Of 229 patients (median age: 49 years), 57 suffered a fragility fracture during the observation period (median observation period: 1558 days). Of 84 premenopausal patients, 5 suffered a fracture. In contrast, of 86 postmenopausal female, 36 suffered a fracture. Fragility fractures were far more frequent than predicted by the FRAX® score. Patients with FRAX® scores over 8.3% had a particularly high risk of fracture.
Conclusions
Fragility fractures associated with high-dose glucocorticoid therapy are common among postmenopausal women. Extreme care should be taken especially for postmenopausal women when high-dose glucocorticoid therapy is required. |
| first_indexed | 2024-12-21T13:30:43Z |
| format | Article |
| id | doaj.art-2deec72ec5f54383a2544a2d16bcc2e8 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-12-21T13:30:43Z |
| publishDate | 2017-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-2deec72ec5f54383a2544a2d16bcc2e82022-12-21T19:02:19ZengElsevierBone Reports2352-18722017-06-016C3810.1016/j.bonr.2016.11.003Very high frequency of fragility fractures associated with high-dose glucocorticoids in postmenopausal women: A retrospective studyGoichi Kageyama0Takaichi Okano1Yuzuru Yamamoto2Keisuke Nishimura3Daisuke Sugiyama4Jun Saegusa5Goh Tsuji6Shunichi Kumagai7Akio Morinobu8Department of Rheumatology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, JapanDepartment of Rheumatology, Kobe University Hospital, Kobe, JapanDepartment of Rheumatology, Kobe University Hospital, Kobe, JapanDepartment of Rheumatology, Kobe University Hospital, Kobe, JapanDepartment of Preventive Medicine and Public Health, Keio University, Tokyo, JapanDepartment of Rheumatology, Kobe University Hospital, Kobe, JapanDepartment of Rheumatology, Shinko Hospital, Kobe, JapanDepartment of Rheumatology, Shinko Hospital, Kobe, JapanDepartment of Rheumatology, Kobe University Hospital, Kobe, JapanPurpose To evaluate the incidence of fragility fractures associated with high-dose glucocorticoid therapy in patients with systemic rheumatic disease. Methods: A retrospective study of patients who were treated with high-dose prednisolone (>0.8 mg/kg) for systemic rheumatic disease at Kobe University Hospital from April 1988 to March 2012. The primary outcome was a major osteoporotic fracture (defined as a clinical vertebral, hip, forearm, or proximal humerus fracture) after high-dose glucocorticoid therapy. For postmenopausal women and men over 40 of age, the patient's fracture risk at the beginning of high-dose glucocorticoid therapy was assessed by the World Health Organization's Fracture Risk Assessment Tool (FRAX®). Results Of 229 patients (median age: 49 years), 57 suffered a fragility fracture during the observation period (median observation period: 1558 days). Of 84 premenopausal patients, 5 suffered a fracture. In contrast, of 86 postmenopausal female, 36 suffered a fracture. Fragility fractures were far more frequent than predicted by the FRAX® score. Patients with FRAX® scores over 8.3% had a particularly high risk of fracture. Conclusions Fragility fractures associated with high-dose glucocorticoid therapy are common among postmenopausal women. Extreme care should be taken especially for postmenopausal women when high-dose glucocorticoid therapy is required.http://www.sciencedirect.com/science/article/pii/S2352187216300511Glucocorticoid induced osteoporosisFragility fractureFRAXHigh-dose glucocorticoid therapyAnd systemic rheumatic disease |
| spellingShingle | Goichi Kageyama Takaichi Okano Yuzuru Yamamoto Keisuke Nishimura Daisuke Sugiyama Jun Saegusa Goh Tsuji Shunichi Kumagai Akio Morinobu Very high frequency of fragility fractures associated with high-dose glucocorticoids in postmenopausal women: A retrospective study Bone Reports Glucocorticoid induced osteoporosis Fragility fracture FRAX High-dose glucocorticoid therapy And systemic rheumatic disease |
| title | Very high frequency of fragility fractures associated with high-dose glucocorticoids in postmenopausal women: A retrospective study |
| title_full | Very high frequency of fragility fractures associated with high-dose glucocorticoids in postmenopausal women: A retrospective study |
| title_fullStr | Very high frequency of fragility fractures associated with high-dose glucocorticoids in postmenopausal women: A retrospective study |
| title_full_unstemmed | Very high frequency of fragility fractures associated with high-dose glucocorticoids in postmenopausal women: A retrospective study |
| title_short | Very high frequency of fragility fractures associated with high-dose glucocorticoids in postmenopausal women: A retrospective study |
| title_sort | very high frequency of fragility fractures associated with high dose glucocorticoids in postmenopausal women a retrospective study |
| topic | Glucocorticoid induced osteoporosis Fragility fracture FRAX High-dose glucocorticoid therapy And systemic rheumatic disease |
| url | http://www.sciencedirect.com/science/article/pii/S2352187216300511 |
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