Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner

Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner

At CA1→subiculum synapses, alternatively spliced neurexin-1 (Nrxn1SS4+) and neurexin-3 (Nrxn3SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation. Nrxn1SS4+ and Nrxn3SS4+ act by binding to secreted cerebellin-2 (Cbln2) that in turn activates pos...

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Bibliographic Details
Main Authors: Jinye Dai, Kif Liakath-Ali, Samantha Rose Golf, Thomas C Südhof
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
synaptic transmission
cerebellins
hippocampus
neurexin signaling specificity
prefrontal cortex
cerebellum
Online Access:https://elifesciences.org/articles/78649

Internet

https://elifesciences.org/articles/78649

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