COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome
Assessing the impact of coronavirus disease 2019 (COVID-19) reveals unique challenges for pregnant women, who experience distinct clinical manifestations and health outcomes compared to their non-pregnant counterparts. We aimed to evaluate the clinical features, disease severity, and health outcome...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-10-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/9748 |
| _version_ | 1797261351749419008 |
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| author | Rozhin Amin Mohammad-Reza Sohrabi Ali-Reza Zali Khatereh Hannani |
| author_facet | Rozhin Amin Mohammad-Reza Sohrabi Ali-Reza Zali Khatereh Hannani |
| author_sort | Rozhin Amin |
| collection | DOAJ |
| description |
Assessing the impact of coronavirus disease 2019 (COVID-19) reveals unique challenges for pregnant women, who experience distinct clinical manifestations and health outcomes compared to their non-pregnant counterparts. We aimed to evaluate the clinical features, disease severity, and health outcomes of COVID-19 in pregnant women and compare them to those of non pregnant women. In this population-based study, we included all women diagnosed with COVID-19 across the province of Tehran during the first two years of the epidemic. Descriptive statistics, the chi-squared test, and the logistic regression model were applied. Overall, 79,338 non-pregnant women and 3249 pregnant women diagnosed with COVID-19 were included. Pregnant women were most commonly in the age group of 25 – 34 years (54%, n = 1758), while the age group of 34–44 had the highest representation among non-pregnant women (56%, n = 44,492). After accounting for age and comorbidities, pregnancy was associated with an increased risk of requiring intensive care (odds ratio [OR] 1.38, confidence interval [CI] 1.223 – 1.564). However, the probability of dying due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was lower in pregnant women compared to non-pregnant women (OR 0.55, CI 0.394–0.793). Cough (41%) and fever (30%) were the most frequent clinical presentations in pregnant women, whereas cough (57%) and muscle ache (38%) were the most common symptoms in non-pregnant women. Furthermore, diarrhea (P < 0.001) and skin lesions (P < 0.001) were reported more frequently by pregnant patients than non-pregnant patients. A significant prevalence of diabetes (P < 0.001), hypertension (P < 0.001), cancers (P < 0.001), and chronic hematological diseases (P < 0.001) was observed in pregnant patients. In conclusion, COVID-19-infected pregnant women exhibit different clinical manifestations and a more severe clinical course but have better health outcomes compared to their non-pregnant counterparts.
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| first_indexed | 2024-04-24T23:39:51Z |
| format | Article |
| id | doaj.art-2df0c83c2fe8487b8db6ea76e291d242 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:51Z |
| publishDate | 2023-10-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-2df0c83c2fe8487b8db6ea76e291d2422024-03-15T13:22:22ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-10-0110.17305/bb.2023.9748COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcomeRozhin Amin0Mohammad-Reza Sohrabi1https://orcid.org/0000-0002-6811-3955Ali-Reza Zali2Khatereh Hannani3Community Medicine Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Social Determinants of Health Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, IranCommunity Medicine Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Social Determinants of Health Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, IranFunctional Neurosurgery Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, IranStatistics and Information Technology Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran Assessing the impact of coronavirus disease 2019 (COVID-19) reveals unique challenges for pregnant women, who experience distinct clinical manifestations and health outcomes compared to their non-pregnant counterparts. We aimed to evaluate the clinical features, disease severity, and health outcomes of COVID-19 in pregnant women and compare them to those of non pregnant women. In this population-based study, we included all women diagnosed with COVID-19 across the province of Tehran during the first two years of the epidemic. Descriptive statistics, the chi-squared test, and the logistic regression model were applied. Overall, 79,338 non-pregnant women and 3249 pregnant women diagnosed with COVID-19 were included. Pregnant women were most commonly in the age group of 25 – 34 years (54%, n = 1758), while the age group of 34–44 had the highest representation among non-pregnant women (56%, n = 44,492). After accounting for age and comorbidities, pregnancy was associated with an increased risk of requiring intensive care (odds ratio [OR] 1.38, confidence interval [CI] 1.223 – 1.564). However, the probability of dying due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was lower in pregnant women compared to non-pregnant women (OR 0.55, CI 0.394–0.793). Cough (41%) and fever (30%) were the most frequent clinical presentations in pregnant women, whereas cough (57%) and muscle ache (38%) were the most common symptoms in non-pregnant women. Furthermore, diarrhea (P < 0.001) and skin lesions (P < 0.001) were reported more frequently by pregnant patients than non-pregnant patients. A significant prevalence of diabetes (P < 0.001), hypertension (P < 0.001), cancers (P < 0.001), and chronic hematological diseases (P < 0.001) was observed in pregnant patients. In conclusion, COVID-19-infected pregnant women exhibit different clinical manifestations and a more severe clinical course but have better health outcomes compared to their non-pregnant counterparts. https://www.bjbms.org/ojs/index.php/bjbms/article/view/9748Coronavirus disease 2019 (COVID-19)disease severityIranpandemicspregnant womensevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| spellingShingle | Rozhin Amin Mohammad-Reza Sohrabi Ali-Reza Zali Khatereh Hannani COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome Biomolecules & Biomedicine Coronavirus disease 2019 (COVID-19) disease severity Iran pandemics pregnant women severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| title | COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome |
| title_full | COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome |
| title_fullStr | COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome |
| title_full_unstemmed | COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome |
| title_short | COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome |
| title_sort | covid 19 in pregnancy a cross sectional study on clinical features disease severity and health outcome |
| topic | Coronavirus disease 2019 (COVID-19) disease severity Iran pandemics pregnant women severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/9748 |
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