Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats

Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats

As the most abundantly used phthalate derivative, di-(2-ethylhexyl) phthalate (DEHP) leads to reproductive disorders, especially in males. Testicular injury can be triggered when the testis is exposed to DEHP during the immature stage. However, the potential mechanism is largely unclear. In the pres...

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Bibliographic Details
Main Authors: Yifan Hong, Yu Zhou, Lianju Shen, Yuexin Wei, Chunlan Long, Yan Fu, Huan Wu, Junke Wang, Yuhao Wu, Shengde Wu, Guanghui Wei
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Ecotoxicology and Environmental Safety
Subjects:
DEHP
ROS
Pyroptosis
Testicular injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321010010

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