Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs
Diabetes has reached epidemic proportions, both in Korea and worldwide and is associated with an increased risk of chronic kidney disease and kidney failure (KF). The natural course of kidney function among people with diabetes (especially type 2 diabetes) may be complex in real-world situations. St...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2022-05-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.kjim.org/upload/pdf/kjim-2021-515.pdf |
| _version_ | 1818160603529740288 |
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| author | Hyo Jin Kim Sang Soo Kim Sang Heon Song |
| author_facet | Hyo Jin Kim Sang Soo Kim Sang Heon Song |
| author_sort | Hyo Jin Kim |
| collection | DOAJ |
| description | Diabetes has reached epidemic proportions, both in Korea and worldwide and is associated with an increased risk of chronic kidney disease and kidney failure (KF). The natural course of kidney function among people with diabetes (especially type 2 diabetes) may be complex in real-world situations. Strong evidence from observational data and clinical trials has demonstrated a consistent association between decreased estimated glomerular filtration rate (eGFR) and subsequent development of hard renal endpoints (such as KF or renal death). The disadvantage of hard renal endpoints is that they require a long follow-up duration. In addition, there are many patients with diabetes whose renal function declines without the appearance of albuminuria, measurement of the eGFR is emphasized. Many studies have used GFR-related parameters, such as its change, decline, or slope, as clinical endpoints for kidney disease progression. In this respect, understanding the trends in GFR changes could be crucial for developing clinical management strategies for the prevention of diabetic complications. This review focuses on the clinical implication of the eGFR-related parameters that have been used so far in diabetic kidney disease. We also discuss the use of recently developed new antidiabetic drugs for kidney protection, with a focus on the GFR as clinical endpoints. |
| first_indexed | 2024-12-11T16:04:30Z |
| format | Article |
| id | doaj.art-2df14d8aeb634232bab133b434fca6c2 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-11T16:04:30Z |
| publishDate | 2022-05-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-2df14d8aeb634232bab133b434fca6c22022-12-22T00:59:13ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482022-05-0137350251910.3904/kjim.2021.515170668Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugsHyo Jin Kim0Sang Soo Kim1Sang Heon Song2 Division of Nephrology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea Biomedical Research Institute, Pusan National University Hospital, Busan, Korea Division of Nephrology, Department of Internal Medicine, Pusan National University Hospital, Busan, KoreaDiabetes has reached epidemic proportions, both in Korea and worldwide and is associated with an increased risk of chronic kidney disease and kidney failure (KF). The natural course of kidney function among people with diabetes (especially type 2 diabetes) may be complex in real-world situations. Strong evidence from observational data and clinical trials has demonstrated a consistent association between decreased estimated glomerular filtration rate (eGFR) and subsequent development of hard renal endpoints (such as KF or renal death). The disadvantage of hard renal endpoints is that they require a long follow-up duration. In addition, there are many patients with diabetes whose renal function declines without the appearance of albuminuria, measurement of the eGFR is emphasized. Many studies have used GFR-related parameters, such as its change, decline, or slope, as clinical endpoints for kidney disease progression. In this respect, understanding the trends in GFR changes could be crucial for developing clinical management strategies for the prevention of diabetic complications. This review focuses on the clinical implication of the eGFR-related parameters that have been used so far in diabetic kidney disease. We also discuss the use of recently developed new antidiabetic drugs for kidney protection, with a focus on the GFR as clinical endpoints.http://www.kjim.org/upload/pdf/kjim-2021-515.pdfdiabetic nephropathiesglomerular filtration ratehypoglycemic agentstreatment outcome |
| spellingShingle | Hyo Jin Kim Sang Soo Kim Sang Heon Song Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs The Korean Journal of Internal Medicine diabetic nephropathies glomerular filtration rate hypoglycemic agents treatment outcome |
| title | Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs |
| title_full | Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs |
| title_fullStr | Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs |
| title_full_unstemmed | Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs |
| title_short | Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs |
| title_sort | glomerular filtration rate as a kidney outcome of diabetic kidney disease a focus on new antidiabetic drugs |
| topic | diabetic nephropathies glomerular filtration rate hypoglycemic agents treatment outcome |
| url | http://www.kjim.org/upload/pdf/kjim-2021-515.pdf |
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