Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies against Delta and Omicron in Mice

Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies against Delta and Omicron in Mice

As existing vaccines fail to completely prevent COVID-19 infections or community transmission, there is an unmet need for vaccines that can better combat SARS-CoV-2 variants of concern (VOC). We previously developed highly thermo-tolerant monomeric and trimeric receptor-binding domain derivatives th...

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Bibliographic Details
Main Authors: Petrus Jansen van Vuren, Alexander J. McAuley, Michael J. Kuiper, Nagendrakumar Balasubramanian Singanallur, Matthew P. Bruce, Shane Riddell, Sarah Goldie, Shruthi Mangalaganesh, Simran Chahal, Trevor W. Drew, Kim R. Blasdell, Mary Tachedjian, Leon Caly, Julian D. Druce, Shahbaz Ahmed, Mohammad Suhail Khan, Sameer Kumar Malladi, Randhir Singh, Suman Pandey, Raghavan Varadarajan, Seshadri S. Vasan
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
AlphaFold
biomolecular modelling
COVID-19
Omicron
receptor-binding domain (RBD)
SARS-CoV-2
Online Access:https://www.mdpi.com/1999-4915/14/4/800

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