Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization
In this paper, composite systems containing curcumin (CUR) were prepared through supercritical-assisted atomization (SAA), using different carriers. Curcumin is particularly interesting in the pharmaceutical and nutraceutical fields for its antioxidant, antitumoral, and anti-inflammatory properties....
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | ChemEngineering |
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| Online Access: | https://www.mdpi.com/2305-7084/5/3/59 |
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| author | Iolanda De Marco Paola Franco |
| author_facet | Iolanda De Marco Paola Franco |
| author_sort | Iolanda De Marco |
| collection | DOAJ |
| description | In this paper, composite systems containing curcumin (CUR) were prepared through supercritical-assisted atomization (SAA), using different carriers. Curcumin is particularly interesting in the pharmaceutical and nutraceutical fields for its antioxidant, antitumoral, and anti-inflammatory properties. However, its therapeutic effect on human health is restricted by its poor water solubility and low dissolution rate, limiting its absorption after its oral administration. To increase the dissolution rate and then the bioavailability of the active compound, CUR was coprecipitated with polymeric, i.e., polyvinylpyrrolidone (PVP) and dextran (DXT), and not polymeric, i.e., hydroxypropyl-β-cyclodextrin (HP-β-CD), carriers. The effects of some operating parameters, namely the concentration of solutes in solution and the active compound/carrier ratio, on the morphology and the particle size distribution of the powders were investigated. Submicrometric particles were produced with all the carriers. Under the best operating conditions, the mean diameters ± standard deviation were equal to 0.69 ± 0.20 μm, 0.40 ± 0.13 μm, and 0.81 ± 0.25 μm for PVP/CUR, DXT/CUR, and HP-β-CD/CUR, respectively. CUR dissolution rates from coprecipitated particles were significantly increased in the case of all the carriers. Therefore, the results are exciting from a pharmaceutical and nutraceutical point of view, to produce supplements containing curcumin, but assuring a high dissolution rate and bioavailability and, consequently, a more effective therapeutic effect. |
| first_indexed | 2024-03-10T07:48:08Z |
| format | Article |
| id | doaj.art-2df52375673c4aaeae8a1dc2e35e8689 |
| institution | Directory Open Access Journal |
| issn | 2305-7084 |
| language | English |
| last_indexed | 2024-03-10T07:48:08Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-2df52375673c4aaeae8a1dc2e35e86892023-11-22T12:27:51ZengMDPI AGChemEngineering2305-70842021-09-01535910.3390/chemengineering5030059Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted AtomizationIolanda De Marco0Paola Franco1Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132 84084 Fisciano, SA, ItalyDepartment of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132 84084 Fisciano, SA, ItalyIn this paper, composite systems containing curcumin (CUR) were prepared through supercritical-assisted atomization (SAA), using different carriers. Curcumin is particularly interesting in the pharmaceutical and nutraceutical fields for its antioxidant, antitumoral, and anti-inflammatory properties. However, its therapeutic effect on human health is restricted by its poor water solubility and low dissolution rate, limiting its absorption after its oral administration. To increase the dissolution rate and then the bioavailability of the active compound, CUR was coprecipitated with polymeric, i.e., polyvinylpyrrolidone (PVP) and dextran (DXT), and not polymeric, i.e., hydroxypropyl-β-cyclodextrin (HP-β-CD), carriers. The effects of some operating parameters, namely the concentration of solutes in solution and the active compound/carrier ratio, on the morphology and the particle size distribution of the powders were investigated. Submicrometric particles were produced with all the carriers. Under the best operating conditions, the mean diameters ± standard deviation were equal to 0.69 ± 0.20 μm, 0.40 ± 0.13 μm, and 0.81 ± 0.25 μm for PVP/CUR, DXT/CUR, and HP-β-CD/CUR, respectively. CUR dissolution rates from coprecipitated particles were significantly increased in the case of all the carriers. Therefore, the results are exciting from a pharmaceutical and nutraceutical point of view, to produce supplements containing curcumin, but assuring a high dissolution rate and bioavailability and, consequently, a more effective therapeutic effect.https://www.mdpi.com/2305-7084/5/3/59SAA coprecipitationbioavailabilitysupercritical carbon dioxidemicrometric particles |
| spellingShingle | Iolanda De Marco Paola Franco Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization ChemEngineering SAA coprecipitation bioavailability supercritical carbon dioxide micrometric particles |
| title | Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization |
| title_full | Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization |
| title_fullStr | Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization |
| title_full_unstemmed | Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization |
| title_short | Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization |
| title_sort | effect of the carrier on the coprecipitation of curcumin through supercritical assisted atomization |
| topic | SAA coprecipitation bioavailability supercritical carbon dioxide micrometric particles |
| url | https://www.mdpi.com/2305-7084/5/3/59 |
| work_keys_str_mv | AT iolandademarco effectofthecarrieronthecoprecipitationofcurcuminthroughsupercriticalassistedatomization AT paolafranco effectofthecarrieronthecoprecipitationofcurcuminthroughsupercriticalassistedatomization |