Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron degenerative disease, and it is hard to diagnose in the early stage, and treatment means are limited, and the treatment effect is unsatisfactory. Therefore, exploring a new effective treatment strategy is urgently needed for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.754630/full |
| _version_ | 1818740448013844480 |
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| author | Ke Wang Yu Li Chao Ren Yongjing Wang Wenshan He Yuan Jiang |
| author_facet | Ke Wang Yu Li Chao Ren Yongjing Wang Wenshan He Yuan Jiang |
| author_sort | Ke Wang |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron degenerative disease, and it is hard to diagnose in the early stage, and treatment means are limited, and the treatment effect is unsatisfactory. Therefore, exploring a new effective treatment strategy is urgently needed for ALS patients. Extracellular vesicles (EVs) are a heterogeneous group of natural membrane vesicles containing many bioactive substances, and they play important roles in the paracrine pathway and exhibit neuroprotection effects. A growing body of evidence shows that EVs have great application potential in diagnosis, treatment, and drug delivery in ALS, and they represent an innovative treatment strategy for ALS. In this review, we will briefly introduce the biogenesis of EVs and focus on discussing the role of EVs in ALS treatment to further enrich and boost the development of EVs as an innovative treatment strategy for ALS. |
| first_indexed | 2024-12-18T01:40:53Z |
| format | Article |
| id | doaj.art-2df7ed3651d94027b14a51bfe69adeef |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-18T01:40:53Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-2df7ed3651d94027b14a51bfe69adeef2022-12-21T21:25:19ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-11-01910.3389/fcell.2021.754630754630Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral SclerosisKe WangYu LiChao RenYongjing WangWenshan HeYuan JiangAmyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron degenerative disease, and it is hard to diagnose in the early stage, and treatment means are limited, and the treatment effect is unsatisfactory. Therefore, exploring a new effective treatment strategy is urgently needed for ALS patients. Extracellular vesicles (EVs) are a heterogeneous group of natural membrane vesicles containing many bioactive substances, and they play important roles in the paracrine pathway and exhibit neuroprotection effects. A growing body of evidence shows that EVs have great application potential in diagnosis, treatment, and drug delivery in ALS, and they represent an innovative treatment strategy for ALS. In this review, we will briefly introduce the biogenesis of EVs and focus on discussing the role of EVs in ALS treatment to further enrich and boost the development of EVs as an innovative treatment strategy for ALS.https://www.frontiersin.org/articles/10.3389/fcell.2021.754630/fullamyotrophic lateral sclerosisextracellular vesiclestreatment strategyexosome-mimicsplant EVs |
| spellingShingle | Ke Wang Yu Li Chao Ren Yongjing Wang Wenshan He Yuan Jiang Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis Frontiers in Cell and Developmental Biology amyotrophic lateral sclerosis extracellular vesicles treatment strategy exosome-mimics plant EVs |
| title | Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis |
| title_full | Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis |
| title_fullStr | Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis |
| title_short | Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis |
| title_sort | extracellular vesicles as innovative treatment strategy for amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis extracellular vesicles treatment strategy exosome-mimics plant EVs |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.754630/full |
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