Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

The development of nonalcoholic fatty liver disease (NAFLD) is associated with increased reactive oxygen species (ROS) production. Previous observations on the contradictory roles of general control nonderepressible 2 (GCN2) in regulating the hepatic redox state under different nutritional condition...

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Bibliographic Details
Main Authors: Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Redox Biology
Subjects:
GCN2
NRF2
KEAP1
Hepatic steatosis
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721003840

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