Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes
The aim of this study was to determine whether plasma levels of carbonylated proteins, total antioxidant capacity (TAC) and reduced protein thiols could be suitable biomarkers of risk factors for diabetic foot. Individuals with type 2 diabetes with normal protective sensation (normal foot group) vs....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto de Tecnologia do Paraná (Tecpar)
2014-04-01
|
| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000200009&lng=en&tlng=en |
| _version_ | 1811302171361148928 |
|---|---|
| author | Ana Carla Pozzi Oliveira Caio Jordão Teixeira Talitha Fernandes Stefanello Marcia Aparecida Carrara Roberto Barbosa Bazotte Anacharis Babeto Sá-Nakanishi Jurandir Fernando Comar Marcia Regina Batista |
| author_facet | Ana Carla Pozzi Oliveira Caio Jordão Teixeira Talitha Fernandes Stefanello Marcia Aparecida Carrara Roberto Barbosa Bazotte Anacharis Babeto Sá-Nakanishi Jurandir Fernando Comar Marcia Regina Batista |
| author_sort | Ana Carla Pozzi Oliveira |
| collection | DOAJ |
| description | The aim of this study was to determine whether plasma levels of carbonylated proteins, total antioxidant capacity (TAC) and reduced protein thiols could be suitable biomarkers of risk factors for diabetic foot. Individuals with type 2 diabetes with normal protective sensation (normal foot group) vs. loss of protective sensation and/or signs of peripheral arterial disease and/or foot deformities and/or history of ulcers and/or neuropathic fractures and/or amputation (diabetic foot group) were compared. The diabetic foot group showed higher carbonylated protein levels (P = 0.0457) and lower levels of TAC (P = 0.0148) and reduced protein thiols (P = 0.0088), compared with the normal foot group. In general, several other parameters of risk of diabetes complication (blood levels of glycated hemoglobin, glucose and cholesterol, duration of diabetes, body mass index and waist circumference) showed a tendency of higher values in the diabetic foot group. The results suggest that the plasma levels of carbonylated proteins, TAC and reduced protein thiols could furnish information about the risk of diabetic foot, considering that the changes in these biomarkers were associated with the loss of sensitivity and foot ulcerations. |
| first_indexed | 2024-04-13T07:24:23Z |
| format | Article |
| id | doaj.art-2df99c6929c24c38b7efcba1739816b1 |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-04-13T07:24:23Z |
| publishDate | 2014-04-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-2df99c6929c24c38b7efcba1739816b12022-12-22T02:56:32ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242014-04-01572223227S1516-89132014000200009Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetesAna Carla Pozzi Oliveira0Caio Jordão Teixeira1Talitha Fernandes Stefanello2Marcia Aparecida Carrara3Roberto Barbosa Bazotte4Anacharis Babeto Sá-Nakanishi5Jurandir Fernando Comar6Marcia Regina Batista7Universidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáThe aim of this study was to determine whether plasma levels of carbonylated proteins, total antioxidant capacity (TAC) and reduced protein thiols could be suitable biomarkers of risk factors for diabetic foot. Individuals with type 2 diabetes with normal protective sensation (normal foot group) vs. loss of protective sensation and/or signs of peripheral arterial disease and/or foot deformities and/or history of ulcers and/or neuropathic fractures and/or amputation (diabetic foot group) were compared. The diabetic foot group showed higher carbonylated protein levels (P = 0.0457) and lower levels of TAC (P = 0.0148) and reduced protein thiols (P = 0.0088), compared with the normal foot group. In general, several other parameters of risk of diabetes complication (blood levels of glycated hemoglobin, glucose and cholesterol, duration of diabetes, body mass index and waist circumference) showed a tendency of higher values in the diabetic foot group. The results suggest that the plasma levels of carbonylated proteins, TAC and reduced protein thiols could furnish information about the risk of diabetic foot, considering that the changes in these biomarkers were associated with the loss of sensitivity and foot ulcerations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000200009&lng=en&tlng=enDiabetic footoxidative stresstotal antioxidant capacityreduced protein thiolsprotein carbonyls |
| spellingShingle | Ana Carla Pozzi Oliveira Caio Jordão Teixeira Talitha Fernandes Stefanello Marcia Aparecida Carrara Roberto Barbosa Bazotte Anacharis Babeto Sá-Nakanishi Jurandir Fernando Comar Marcia Regina Batista Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes Brazilian Archives of Biology and Technology Diabetic foot oxidative stress total antioxidant capacity reduced protein thiols protein carbonyls |
| title | Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes |
| title_full | Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes |
| title_fullStr | Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes |
| title_full_unstemmed | Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes |
| title_short | Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes |
| title_sort | oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes |
| topic | Diabetic foot oxidative stress total antioxidant capacity reduced protein thiols protein carbonyls |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000200009&lng=en&tlng=en |
| work_keys_str_mv | AT anacarlapozzioliveira oxidativestressparametersasbiomarkersofriskfactorfordiabeticfootamongthepatientswithtype2diabetes AT caiojordaoteixeira oxidativestressparametersasbiomarkersofriskfactorfordiabeticfootamongthepatientswithtype2diabetes AT talithafernandesstefanello oxidativestressparametersasbiomarkersofriskfactorfordiabeticfootamongthepatientswithtype2diabetes AT marciaaparecidacarrara oxidativestressparametersasbiomarkersofriskfactorfordiabeticfootamongthepatientswithtype2diabetes AT robertobarbosabazotte oxidativestressparametersasbiomarkersofriskfactorfordiabeticfootamongthepatientswithtype2diabetes AT anacharisbabetosanakanishi oxidativestressparametersasbiomarkersofriskfactorfordiabeticfootamongthepatientswithtype2diabetes AT jurandirfernandocomar oxidativestressparametersasbiomarkersofriskfactorfordiabeticfootamongthepatientswithtype2diabetes AT marciareginabatista oxidativestressparametersasbiomarkersofriskfactorfordiabeticfootamongthepatientswithtype2diabetes |