Pertussis in Lao PDR: Seroprevalence and disease
Objectives: Pertussis is a debilitating vaccine-preventable infection. The aim of this study was to determine susceptibility and exposure to pertussis in Lao PDR in different age groups and subpopulations. Methods: A total 3072 serum samples were obtained from different cohorts: children with docume...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220302071 |
| _version_ | 1818138088368504832 |
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| author | Daria Kleine Somxay Billamay Phetsavanh Chanthavilay Sodaly Mongkhoune Chirapha Keokhamphoui Chanthala Souksakhone Phonethipsavanh Nouanthong Bouaphan Khamphaphongphane Claude P. Muller Antony P. Black |
| author_facet | Daria Kleine Somxay Billamay Phetsavanh Chanthavilay Sodaly Mongkhoune Chirapha Keokhamphoui Chanthala Souksakhone Phonethipsavanh Nouanthong Bouaphan Khamphaphongphane Claude P. Muller Antony P. Black |
| author_sort | Daria Kleine |
| collection | DOAJ |
| description | Objectives: Pertussis is a debilitating vaccine-preventable infection. The aim of this study was to determine susceptibility and exposure to pertussis in Lao PDR in different age groups and subpopulations. Methods: A total 3072 serum samples were obtained from different cohorts: children with documented vaccination, pre-schoolers, schoolchildren, blood donors, healthcare workers (HCWs), and pregnant women and paired cord blood. Samples were tested for anti-pertussis toxin IgG antibodies. A history of Bordetella pertussis exposure was defined according to antibody titres. Four hundred and seventy-five throat swabs and nasopharyngeal aspirates were analysed by PCR for the presence of B. pertussis in symptomatic children at the Children's Hospital in Vientiane. Results: Overall pertussis seroprevalence was 57.5%. The prevalence of titres indicating acute infection or recent vaccination or infection/vaccination within the last 12 months ranged from 7.4% (100/1356) in adults to 21.4% (25/117) in pre-schoolers (age 1–5 years). B. pertussis was detected in 1.05% (5/475) of children with respiratory symptoms in Vientiane Capital. Conclusions: It is suggested that routine childhood vaccination, in particular outreach, as well as vaccination of HCWs should be strengthened. A childhood booster and vaccination of pregnant mothers should be considered. There is also a need to improve reporting and to introduce pertussis testing in at least one central facility. |
| first_indexed | 2024-12-11T10:06:38Z |
| format | Article |
| id | doaj.art-2dfa62173f82489ca4911a2051cbfb32 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-11T10:06:38Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-2dfa62173f82489ca4911a2051cbfb322022-12-22T01:11:55ZengElsevierInternational Journal of Infectious Diseases1201-97122020-06-0195282287Pertussis in Lao PDR: Seroprevalence and diseaseDaria Kleine0Somxay Billamay1Phetsavanh Chanthavilay2Sodaly Mongkhoune3Chirapha Keokhamphoui4Chanthala Souksakhone5Phonethipsavanh Nouanthong6Bouaphan Khamphaphongphane7Claude P. Muller8Antony P. Black9Department of Infection and Immunity, Luxembourg Institute of Health, 1445 Strassen, Esch-sur-Alzette, LuxembourgChildren's Hospital, Vientiane, LaosUniversity of Health Sciences, Vientiane, LaosChildren's Hospital, Vientiane, LaosNational Blood Transfusion Centre, Lao Red Cross, Vientiane, LaosNational Blood Transfusion Centre, Lao Red Cross, Vientiane, LaosInstitut Pasteur du Laos, Vientiane, LaosNational Centre for Laboratory and Epidemiology, Vientiane, LaosDepartment of Infection and Immunity, Luxembourg Institute of Health, 1445 Strassen, Esch-sur-Alzette, Luxembourg; Institut Pasteur du Laos, Vientiane, LaosInstitut Pasteur du Laos, Vientiane, Laos; Corresponding author at: Institut Pasteur du Laos, Rue Samsenthai, Vientiane, Laos.Objectives: Pertussis is a debilitating vaccine-preventable infection. The aim of this study was to determine susceptibility and exposure to pertussis in Lao PDR in different age groups and subpopulations. Methods: A total 3072 serum samples were obtained from different cohorts: children with documented vaccination, pre-schoolers, schoolchildren, blood donors, healthcare workers (HCWs), and pregnant women and paired cord blood. Samples were tested for anti-pertussis toxin IgG antibodies. A history of Bordetella pertussis exposure was defined according to antibody titres. Four hundred and seventy-five throat swabs and nasopharyngeal aspirates were analysed by PCR for the presence of B. pertussis in symptomatic children at the Children's Hospital in Vientiane. Results: Overall pertussis seroprevalence was 57.5%. The prevalence of titres indicating acute infection or recent vaccination or infection/vaccination within the last 12 months ranged from 7.4% (100/1356) in adults to 21.4% (25/117) in pre-schoolers (age 1–5 years). B. pertussis was detected in 1.05% (5/475) of children with respiratory symptoms in Vientiane Capital. Conclusions: It is suggested that routine childhood vaccination, in particular outreach, as well as vaccination of HCWs should be strengthened. A childhood booster and vaccination of pregnant mothers should be considered. There is also a need to improve reporting and to introduce pertussis testing in at least one central facility.http://www.sciencedirect.com/science/article/pii/S1201971220302071Bordetella pertussisSeroprevalenceLao PDRVaccine immunogenicityVaccine-preventable infection |
| spellingShingle | Daria Kleine Somxay Billamay Phetsavanh Chanthavilay Sodaly Mongkhoune Chirapha Keokhamphoui Chanthala Souksakhone Phonethipsavanh Nouanthong Bouaphan Khamphaphongphane Claude P. Muller Antony P. Black Pertussis in Lao PDR: Seroprevalence and disease International Journal of Infectious Diseases Bordetella pertussis Seroprevalence Lao PDR Vaccine immunogenicity Vaccine-preventable infection |
| title | Pertussis in Lao PDR: Seroprevalence and disease |
| title_full | Pertussis in Lao PDR: Seroprevalence and disease |
| title_fullStr | Pertussis in Lao PDR: Seroprevalence and disease |
| title_full_unstemmed | Pertussis in Lao PDR: Seroprevalence and disease |
| title_short | Pertussis in Lao PDR: Seroprevalence and disease |
| title_sort | pertussis in lao pdr seroprevalence and disease |
| topic | Bordetella pertussis Seroprevalence Lao PDR Vaccine immunogenicity Vaccine-preventable infection |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220302071 |
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