Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal Outcome
Limited data are available on outcomes among COVID-19 patients beyond the acute phase of the disease. All-cause mortality among our COVID-19 patients one year after hospital discharge and factors/conditions associated with death were evaluated. All patients discharged from our COVID center were peri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/17/5691 |
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| author | Domenico Cozzolino Ciro Romano Celestino Sardu Riccardo Nevola Giuseppina Rosaria Umano Luca Rinaldi Luigi Elio Adinolfi Christian Catalini Aldo Marrone Maurizio Municinò Ferdinando Carlo Sasso Raffaele Marfella |
| author_facet | Domenico Cozzolino Ciro Romano Celestino Sardu Riccardo Nevola Giuseppina Rosaria Umano Luca Rinaldi Luigi Elio Adinolfi Christian Catalini Aldo Marrone Maurizio Municinò Ferdinando Carlo Sasso Raffaele Marfella |
| author_sort | Domenico Cozzolino |
| collection | DOAJ |
| description | Limited data are available on outcomes among COVID-19 patients beyond the acute phase of the disease. All-cause mortality among our COVID-19 patients one year after hospital discharge and factors/conditions associated with death were evaluated. All patients discharged from our COVID center were periodically evaluated by clinical assessment and by digital healthcare registry consultation. All findings acquired on discharge day represented the baseline data and were utilized for statistics. Of the 208 patients admitted, 187 patients were discharged. Among these, 17 patients died within 12 months (non-survivors). Compared to survivors, non-survivor patients were significantly (<i>p</i> < 0.05) older, exhibited significantly greater comorbidities and prevalence of active malignancy, heart failure, and arrhythmias, and showed significantly higher circulating levels of B-type natriuretic peptide, troponin, C-reactive protein, and d-dimer, as well as a longer heart-rate-corrected QT interval and significantly lower values for the glomerular filtration rate. Following multivariate analysis, cancer, arrhythmias, and high C-reactive protein levels were found to be factors independently associated with death. At the one-year follow-up, about 9% of patients discharged from our COVID center had a fatal outcome. Ageing, myocardial injury, impaired renal function, and, in particular, cancer, hyperinflammation, and arrhythmias represented strong predictors of the worst long-term outcome among COVID-19 patients. |
| first_indexed | 2024-03-10T23:19:16Z |
| format | Article |
| id | doaj.art-2dfaa287bc874a529f4f3d925dc73429 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:19:16Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2dfaa287bc874a529f4f3d925dc734292023-11-19T08:24:03ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011217569110.3390/jcm12175691Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal OutcomeDomenico Cozzolino0Ciro Romano1Celestino Sardu2Riccardo Nevola3Giuseppina Rosaria Umano4Luca Rinaldi5Luigi Elio Adinolfi6Christian Catalini7Aldo Marrone8Maurizio Municinò9Ferdinando Carlo Sasso10Raffaele Marfella11Department of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of the Woman and the Child and of General and Specialized Surgery, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Forensic, Evaluative and Necroscopic Medicine, ASL Napoli 2 Nord, 80027 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyLimited data are available on outcomes among COVID-19 patients beyond the acute phase of the disease. All-cause mortality among our COVID-19 patients one year after hospital discharge and factors/conditions associated with death were evaluated. All patients discharged from our COVID center were periodically evaluated by clinical assessment and by digital healthcare registry consultation. All findings acquired on discharge day represented the baseline data and were utilized for statistics. Of the 208 patients admitted, 187 patients were discharged. Among these, 17 patients died within 12 months (non-survivors). Compared to survivors, non-survivor patients were significantly (<i>p</i> < 0.05) older, exhibited significantly greater comorbidities and prevalence of active malignancy, heart failure, and arrhythmias, and showed significantly higher circulating levels of B-type natriuretic peptide, troponin, C-reactive protein, and d-dimer, as well as a longer heart-rate-corrected QT interval and significantly lower values for the glomerular filtration rate. Following multivariate analysis, cancer, arrhythmias, and high C-reactive protein levels were found to be factors independently associated with death. At the one-year follow-up, about 9% of patients discharged from our COVID center had a fatal outcome. Ageing, myocardial injury, impaired renal function, and, in particular, cancer, hyperinflammation, and arrhythmias represented strong predictors of the worst long-term outcome among COVID-19 patients.https://www.mdpi.com/2077-0383/12/17/5691COVID-19long-term follow-upall-cause mortalitydeath predictors |
| spellingShingle | Domenico Cozzolino Ciro Romano Celestino Sardu Riccardo Nevola Giuseppina Rosaria Umano Luca Rinaldi Luigi Elio Adinolfi Christian Catalini Aldo Marrone Maurizio Municinò Ferdinando Carlo Sasso Raffaele Marfella Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal Outcome Journal of Clinical Medicine COVID-19 long-term follow-up all-cause mortality death predictors |
| title | Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal Outcome |
| title_full | Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal Outcome |
| title_fullStr | Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal Outcome |
| title_full_unstemmed | Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal Outcome |
| title_short | Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal Outcome |
| title_sort | long term prognosis among covid 19 patients the predictive role played by hyperinflammation and arrhythmic disorders in fatal outcome |
| topic | COVID-19 long-term follow-up all-cause mortality death predictors |
| url | https://www.mdpi.com/2077-0383/12/17/5691 |
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