Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea

Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spect...

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Bibliographic Details
Main Authors: Daniel Torres-Mendoza, Yisett González, José Félix Gómez-Reyes, Héctor M. Guzmán, José Luis López-Perez, William H. Gerwick, Patricia L. Fernandez, Marcelino Gutiérrez
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
Eunicea succinea
cembranolide diterpenes
uprolides
anti-inflammatory
Online Access:http://www.mdpi.com/1420-3049/21/6/819
Description
Summary:Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1–3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages.
ISSN:1420-3049

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