Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea
Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spect...
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MDPI AG
2016-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/6/819 |
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| author | Daniel Torres-Mendoza Yisett González José Félix Gómez-Reyes Héctor M. Guzmán José Luis López-Perez William H. Gerwick Patricia L. Fernandez Marcelino Gutiérrez |
| author_facet | Daniel Torres-Mendoza Yisett González José Félix Gómez-Reyes Héctor M. Guzmán José Luis López-Perez William H. Gerwick Patricia L. Fernandez Marcelino Gutiérrez |
| author_sort | Daniel Torres-Mendoza |
| collection | DOAJ |
| description | Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1–3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages. |
| first_indexed | 2024-12-19T06:15:45Z |
| format | Article |
| id | doaj.art-2dfaae8b23bd4f02a153807eac81fb2d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T06:15:45Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2dfaae8b23bd4f02a153807eac81fb2d2022-12-21T20:32:51ZengMDPI AGMolecules1420-30492016-06-0121681910.3390/molecules21060819molecules21060819Uprolides N, O and P from the Panamanian Octocoral Eunicea succineaDaniel Torres-Mendoza0Yisett González1José Félix Gómez-Reyes2Héctor M. Guzmán3José Luis López-Perez4William H. Gerwick5Patricia L. Fernandez6Marcelino Gutiérrez7Center for Biodiversity and Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge 0843-01103, PanamaDepartment of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, IndiaCenter for Biodiversity and Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge 0843-01103, PanamaSmithsonian Tropical Research Institute, Balboa, Ancon 0843-03092, PanamaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, University of Salamanca, Ave. Campo Charro, s/n, Salamanca 37007, SpainCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92037, USACenter for Molecular and Cellular Biology of Diseases, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge 0843-01103, PanamaCenter for Biodiversity and Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge 0843-01103, PanamaThree new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1–3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages.http://www.mdpi.com/1420-3049/21/6/819Eunicea succineacembranolide diterpenesuprolidesanti-inflammatory |
| spellingShingle | Daniel Torres-Mendoza Yisett González José Félix Gómez-Reyes Héctor M. Guzmán José Luis López-Perez William H. Gerwick Patricia L. Fernandez Marcelino Gutiérrez Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea Molecules Eunicea succinea cembranolide diterpenes uprolides anti-inflammatory |
| title | Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea |
| title_full | Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea |
| title_fullStr | Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea |
| title_full_unstemmed | Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea |
| title_short | Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea |
| title_sort | uprolides n o and p from the panamanian octocoral eunicea succinea |
| topic | Eunicea succinea cembranolide diterpenes uprolides anti-inflammatory |
| url | http://www.mdpi.com/1420-3049/21/6/819 |
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