Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort study
BackgroundThe aim was to investigate gestational age at birth of women after induction of fetal lung maturation (antenatal corticosteroids = ACS) because of imminent preterm birth (PTB), and to quantify incidence of late PTB (gestational age < 260 days) and extreme immaturity (gestational age...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1285306/full |
| _version_ | 1797361326283030528 |
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| author | Joachim Graf Harald Abele Harald Abele Jan Pauluschke-Fröhlich |
| author_facet | Joachim Graf Harald Abele Harald Abele Jan Pauluschke-Fröhlich |
| author_sort | Joachim Graf |
| collection | DOAJ |
| description | BackgroundThe aim was to investigate gestational age at birth of women after induction of fetal lung maturation (antenatal corticosteroids = ACS) because of imminent preterm birth (PTB), and to quantify incidence of late PTB (gestational age < 260 days) and extreme immaturity (gestational age < 196 days) in relation to several diagnoses (PPROM, placental bleeding, premature labor, preeclampsia, oligohydramnios, amniotic infection syndrome (AIS), cervical insufficiency) and risk factors (age > 35, history of preterm delivery, multifetal gestation, gestational diabetes, hypertension, nicotine abuse).MethodsThe study was designed as a retrospective cohort trial, in which the data of all births taking place in 2016 in the German federal state Rhineland-Palatinate were evaluated. Frequency analyses, subgroup analysis (Chi-square tests and Friedman’s tests), as well as multinomial logistic regressions and linear regressions were used to determine odds ratios (OR).ResultsIn total, N = 1,544 patients were included who had been hospitalized due to an imminent PTB and had received ACS, of whom 52% had a late PTB and 8% a PTB with extreme immaturity. Regarding the gestational age at birth, there were only minor differences between the individual risk factors and diagnoses, only AIS patients showed a significantly lower gestational age (mean: 207 days). A significantly increased risk of PTB with extreme immaturity was found in patients with AIS (OR = 5.57) or placental bleeding (OR = 2.10).ConclusionThere is a need for further research in order to be able to apply therapeutic measures more accurately in relation to risk factors and diagnoses. |
| first_indexed | 2024-03-08T15:52:28Z |
| format | Article |
| id | doaj.art-2dfbb80f6ea9467984120da4e0192c1d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-08T15:52:28Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-2dfbb80f6ea9467984120da4e0192c1d2024-01-09T04:20:42ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-01-011010.3389/fmed.2023.12853061285306Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort studyJoachim Graf0Harald Abele1Harald Abele2Jan Pauluschke-Fröhlich3Midwifery Science, Institute for Health Sciences, University Hospital Tübingen, Tübingen, GermanyMidwifery Science, Institute for Health Sciences, University Hospital Tübingen, Tübingen, GermanyDepartment of Women’s Health, University Hospital Tübingen, Tübingen, GermanyDepartment of Women’s Health, University Hospital Tübingen, Tübingen, GermanyBackgroundThe aim was to investigate gestational age at birth of women after induction of fetal lung maturation (antenatal corticosteroids = ACS) because of imminent preterm birth (PTB), and to quantify incidence of late PTB (gestational age < 260 days) and extreme immaturity (gestational age < 196 days) in relation to several diagnoses (PPROM, placental bleeding, premature labor, preeclampsia, oligohydramnios, amniotic infection syndrome (AIS), cervical insufficiency) and risk factors (age > 35, history of preterm delivery, multifetal gestation, gestational diabetes, hypertension, nicotine abuse).MethodsThe study was designed as a retrospective cohort trial, in which the data of all births taking place in 2016 in the German federal state Rhineland-Palatinate were evaluated. Frequency analyses, subgroup analysis (Chi-square tests and Friedman’s tests), as well as multinomial logistic regressions and linear regressions were used to determine odds ratios (OR).ResultsIn total, N = 1,544 patients were included who had been hospitalized due to an imminent PTB and had received ACS, of whom 52% had a late PTB and 8% a PTB with extreme immaturity. Regarding the gestational age at birth, there were only minor differences between the individual risk factors and diagnoses, only AIS patients showed a significantly lower gestational age (mean: 207 days). A significantly increased risk of PTB with extreme immaturity was found in patients with AIS (OR = 5.57) or placental bleeding (OR = 2.10).ConclusionThere is a need for further research in order to be able to apply therapeutic measures more accurately in relation to risk factors and diagnoses.https://www.frontiersin.org/articles/10.3389/fmed.2023.1285306/fullpremature birthgestational age at birthAISextreme immaturityPPROM |
| spellingShingle | Joachim Graf Harald Abele Harald Abele Jan Pauluschke-Fröhlich Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort study Frontiers in Medicine premature birth gestational age at birth AIS extreme immaturity PPROM |
| title | Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort study |
| title_full | Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort study |
| title_fullStr | Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort study |
| title_full_unstemmed | Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort study |
| title_short | Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort study |
| title_sort | gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors a retrospective cohort study |
| topic | premature birth gestational age at birth AIS extreme immaturity PPROM |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1285306/full |
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