Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impacts
Abstract Peritoneal adhesion is a significant problem following gastrointestinal surgeries, accompanied by a significant economic burden and morbidity for patients. Punica granatum seed oil (PSO) possesses antioxidative, anti‐inflammatory, and anticancer effects. Thus, we aimed to evaluate the antip...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15545 |
| _version_ | 1827589619879772160 |
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| author | Hassan Rakhshandeh Vafa Baradaran Rahimi Zahra Habibi Zahra Sirousi Vahid Reza Askari |
| author_facet | Hassan Rakhshandeh Vafa Baradaran Rahimi Zahra Habibi Zahra Sirousi Vahid Reza Askari |
| author_sort | Hassan Rakhshandeh |
| collection | DOAJ |
| description | Abstract Peritoneal adhesion is a significant problem following gastrointestinal surgeries, accompanied by a significant economic burden and morbidity for patients. Punica granatum seed oil (PSO) possesses antioxidative, anti‐inflammatory, and anticancer effects. Thus, we aimed to evaluate the antiperitoneal adhesive properties of PSO in rats. Forty‐eight Wistar rats (200–250 g) were randomly and equally divided into six groups: sham group, control group; peritoneal adhesion without any treatment, vehicle group; peritoneal adhesion with saline + Tween‐80.5% treatment, and experimental groups; peritoneal adhesion with 0.5%, 1.5%, and 4.5% v/v PSO treatment. In addition, peritoneal adhesion was examined macroscopically along with evaluating the oxidative stress (malondialdehyde [MDA], nitric oxide [NO], and glutathione [GSH]) inflammatory (interleukin [IL]‐6, IL‐1β, and tumor necrosis factor‐α [TNF‐α]), fibrotic (transforming growth factor‐β [TGF‐β]), and angiogenic (vascular endothelial growth factor [VEGF]) factors. Our results revealed that the levels of adhesion scores, MDA, NO, IL‐6, TNF‐α, IL‐1β, TGF‐β, and VEGF, were propagated in the vehicle group while the GSH level was alleviated (p < 0.001). In contrast, premedication with PSO, especially at the lowest concentration, notably lessened the levels of adhesion scores, MDA, NO, IL‐6, TNF‐α, IL‐1β, TGF‐β, and VEGF as well as GSH in comparison to the vehicle group following the peritoneal adhesion induction (p < 0.001–0.05). As a result, PSO may prevent peritoneal adhesion through its antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic properties. Therefore, PSO could be considered a beneficial candidate for the treatment of postoperative peritoneal adhesion. |
| first_indexed | 2024-03-09T01:04:29Z |
| format | Article |
| id | doaj.art-2dfc753bdcdf410b86aa29d3933e5a04 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-09T01:04:29Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-2dfc753bdcdf410b86aa29d3933e5a042023-12-11T10:30:37ZengWileyPhysiological Reports2051-817X2022-12-011024n/an/a10.14814/phy2.15545Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impactsHassan Rakhshandeh0Vafa Baradaran Rahimi1Zahra Habibi2Zahra Sirousi3Vahid Reza Askari4Pharmacological Research Center of Medicinal Plants Mashhad University of Medical Sciences Mashhad IranDepartment of Cardiovascular Diseases, Faculty of Medicine Mashhad University of Medical Sciences Mashhad IranPharmacological Research Center of Medicinal Plants Mashhad University of Medical Sciences Mashhad IranPharmacological Research Center of Medicinal Plants Mashhad University of Medical Sciences Mashhad IranInternational UNESCO Center for Health‐Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences Mashhad IranAbstract Peritoneal adhesion is a significant problem following gastrointestinal surgeries, accompanied by a significant economic burden and morbidity for patients. Punica granatum seed oil (PSO) possesses antioxidative, anti‐inflammatory, and anticancer effects. Thus, we aimed to evaluate the antiperitoneal adhesive properties of PSO in rats. Forty‐eight Wistar rats (200–250 g) were randomly and equally divided into six groups: sham group, control group; peritoneal adhesion without any treatment, vehicle group; peritoneal adhesion with saline + Tween‐80.5% treatment, and experimental groups; peritoneal adhesion with 0.5%, 1.5%, and 4.5% v/v PSO treatment. In addition, peritoneal adhesion was examined macroscopically along with evaluating the oxidative stress (malondialdehyde [MDA], nitric oxide [NO], and glutathione [GSH]) inflammatory (interleukin [IL]‐6, IL‐1β, and tumor necrosis factor‐α [TNF‐α]), fibrotic (transforming growth factor‐β [TGF‐β]), and angiogenic (vascular endothelial growth factor [VEGF]) factors. Our results revealed that the levels of adhesion scores, MDA, NO, IL‐6, TNF‐α, IL‐1β, TGF‐β, and VEGF, were propagated in the vehicle group while the GSH level was alleviated (p < 0.001). In contrast, premedication with PSO, especially at the lowest concentration, notably lessened the levels of adhesion scores, MDA, NO, IL‐6, TNF‐α, IL‐1β, TGF‐β, and VEGF as well as GSH in comparison to the vehicle group following the peritoneal adhesion induction (p < 0.001–0.05). As a result, PSO may prevent peritoneal adhesion through its antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic properties. Therefore, PSO could be considered a beneficial candidate for the treatment of postoperative peritoneal adhesion.https://doi.org/10.14814/phy2.15545anti‐inflammatoryantioxidantperitoneal adhesionpomegranate seed oilPunica granatum |
| spellingShingle | Hassan Rakhshandeh Vafa Baradaran Rahimi Zahra Habibi Zahra Sirousi Vahid Reza Askari Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impacts Physiological Reports anti‐inflammatory antioxidant peritoneal adhesion pomegranate seed oil Punica granatum |
| title | Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impacts |
| title_full | Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impacts |
| title_fullStr | Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impacts |
| title_full_unstemmed | Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impacts |
| title_short | Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impacts |
| title_sort | punica granatum seed oil detracts peritoneal adhesion perusing antioxidant anti inflammatory antifibrotic and antiangiogenic impacts |
| topic | anti‐inflammatory antioxidant peritoneal adhesion pomegranate seed oil Punica granatum |
| url | https://doi.org/10.14814/phy2.15545 |
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