Unraveling the Gut Microbiome–Diet Connection: Exploring the Impact of Digital Precision and Personalized Nutrition on Microbiota Composition and Host Physiology
The human gut microbiome, an intricate ecosystem housing trillions of microorganisms within the gastrointestinal tract, holds significant importance in human health and the development of diseases. Recent advances in technology have allowed for an in-depth exploration of the gut microbiome, shedding...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/18/3931 |
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| author | Giada Bianchetti Flavio De Maio Alessio Abeltino Cassandra Serantoni Alessia Riente Giulia Santarelli Maurizio Sanguinetti Giovanni Delogu Roberta Martinoli Silvia Barbaresi Marco De Spirito Giuseppe Maulucci |
| author_facet | Giada Bianchetti Flavio De Maio Alessio Abeltino Cassandra Serantoni Alessia Riente Giulia Santarelli Maurizio Sanguinetti Giovanni Delogu Roberta Martinoli Silvia Barbaresi Marco De Spirito Giuseppe Maulucci |
| author_sort | Giada Bianchetti |
| collection | DOAJ |
| description | The human gut microbiome, an intricate ecosystem housing trillions of microorganisms within the gastrointestinal tract, holds significant importance in human health and the development of diseases. Recent advances in technology have allowed for an in-depth exploration of the gut microbiome, shedding light on its composition and functions. Of particular interest is the role of diet in shaping the gut microbiome, influencing its diversity, population size, and metabolic functions. Precision nutrition, a personalized approach based on individual characteristics, has shown promise in directly impacting the composition of the gut microbiome. However, to fully understand the long-term effects of specific diets and food components on the gut microbiome and to identify the variations between individuals, longitudinal studies are crucial. Additionally, precise methods for collecting dietary data, alongside the application of machine learning techniques, hold immense potential in comprehending the gut microbiome’s response to diet and providing tailored lifestyle recommendations. In this study, we investigated the complex mechanisms that govern the diverse impacts of nutrients and specific foods on the equilibrium and functioning of the individual gut microbiome of seven volunteers (four females and three males) with an average age of 40.9 ± 10.3 years, aiming at identifying potential therapeutic targets, thus making valuable contributions to the field of personalized nutrition. These findings have the potential to revolutionize the development of highly effective strategies that are tailored to individual requirements for the management and treatment of various diseases. |
| first_indexed | 2024-03-10T22:20:06Z |
| format | Article |
| id | doaj.art-2dfe07f57f3b4785aadb3362b4025f48 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T22:20:06Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-2dfe07f57f3b4785aadb3362b4025f482023-11-19T12:17:53ZengMDPI AGNutrients2072-66432023-09-011518393110.3390/nu15183931Unraveling the Gut Microbiome–Diet Connection: Exploring the Impact of Digital Precision and Personalized Nutrition on Microbiota Composition and Host PhysiologyGiada Bianchetti0Flavio De Maio1Alessio Abeltino2Cassandra Serantoni3Alessia Riente4Giulia Santarelli5Maurizio Sanguinetti6Giovanni Delogu7Roberta Martinoli8Silvia Barbaresi9Marco De Spirito10Giuseppe Maulucci11Department of Neuroscience, Biophysics Sections, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, 00168 Rome, ItalyDepartment of Neuroscience, Biophysics Sections, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyDepartment of Neuroscience, Biophysics Sections, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyDepartment of Neuroscience, Biophysics Sections, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, 00168 Rome, ItalyDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, 00168 Rome, ItalyDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, ItalySocietà Italiana di Medicina Estetica, 00195 Rome, ItalyDepartment of Movement and Sports Sciences, Faculty of Medicine and Health Sciences, Watersportlaan 2, Ghent University, 9000 Ghent, BelgiumDepartment of Neuroscience, Biophysics Sections, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyDepartment of Neuroscience, Biophysics Sections, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyThe human gut microbiome, an intricate ecosystem housing trillions of microorganisms within the gastrointestinal tract, holds significant importance in human health and the development of diseases. Recent advances in technology have allowed for an in-depth exploration of the gut microbiome, shedding light on its composition and functions. Of particular interest is the role of diet in shaping the gut microbiome, influencing its diversity, population size, and metabolic functions. Precision nutrition, a personalized approach based on individual characteristics, has shown promise in directly impacting the composition of the gut microbiome. However, to fully understand the long-term effects of specific diets and food components on the gut microbiome and to identify the variations between individuals, longitudinal studies are crucial. Additionally, precise methods for collecting dietary data, alongside the application of machine learning techniques, hold immense potential in comprehending the gut microbiome’s response to diet and providing tailored lifestyle recommendations. In this study, we investigated the complex mechanisms that govern the diverse impacts of nutrients and specific foods on the equilibrium and functioning of the individual gut microbiome of seven volunteers (four females and three males) with an average age of 40.9 ± 10.3 years, aiming at identifying potential therapeutic targets, thus making valuable contributions to the field of personalized nutrition. These findings have the potential to revolutionize the development of highly effective strategies that are tailored to individual requirements for the management and treatment of various diseases.https://www.mdpi.com/2072-6643/15/18/3931precision nutritiongut microbiomedietary interventionlongitudinal studiesnutrigenomicspersonalized medicine |
| spellingShingle | Giada Bianchetti Flavio De Maio Alessio Abeltino Cassandra Serantoni Alessia Riente Giulia Santarelli Maurizio Sanguinetti Giovanni Delogu Roberta Martinoli Silvia Barbaresi Marco De Spirito Giuseppe Maulucci Unraveling the Gut Microbiome–Diet Connection: Exploring the Impact of Digital Precision and Personalized Nutrition on Microbiota Composition and Host Physiology Nutrients precision nutrition gut microbiome dietary intervention longitudinal studies nutrigenomics personalized medicine |
| title | Unraveling the Gut Microbiome–Diet Connection: Exploring the Impact of Digital Precision and Personalized Nutrition on Microbiota Composition and Host Physiology |
| title_full | Unraveling the Gut Microbiome–Diet Connection: Exploring the Impact of Digital Precision and Personalized Nutrition on Microbiota Composition and Host Physiology |
| title_fullStr | Unraveling the Gut Microbiome–Diet Connection: Exploring the Impact of Digital Precision and Personalized Nutrition on Microbiota Composition and Host Physiology |
| title_full_unstemmed | Unraveling the Gut Microbiome–Diet Connection: Exploring the Impact of Digital Precision and Personalized Nutrition on Microbiota Composition and Host Physiology |
| title_short | Unraveling the Gut Microbiome–Diet Connection: Exploring the Impact of Digital Precision and Personalized Nutrition on Microbiota Composition and Host Physiology |
| title_sort | unraveling the gut microbiome diet connection exploring the impact of digital precision and personalized nutrition on microbiota composition and host physiology |
| topic | precision nutrition gut microbiome dietary intervention longitudinal studies nutrigenomics personalized medicine |
| url | https://www.mdpi.com/2072-6643/15/18/3931 |
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