Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status

Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status

<p>Abstract</p> <p>Background</p> <p>In the bone marrow, hematopietic and mesenchymal stem cells form a unique niche in which the oxygen tension is low. Hypoxia may have a role in maintaining stem cell fate, self renewal and multipotency. However, whereas most studies a...

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Bibliographic Details
Main Authors: de Carvalho Marcelo, de Isla Natalia, Foliguet Bernard, Nemos Christophe, Basciano Leticia, Tran Nguyen, Dalloul Ali
Format: Article
Language:English
Published: BMC 2011-03-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/12/12

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