Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges
Researchers have sought to understand how language is processed in the brain, how brain damage affects language abilities, and what can be expected during the recovery period since the early 19th century. In this review, we first discuss mechanisms of damage and plasticity in the post-stroke brain,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00295/full |
| _version_ | 1811281148649668608 |
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| author | Swathi Kiran Cynthia K. Thompson Cynthia K. Thompson |
| author_facet | Swathi Kiran Cynthia K. Thompson Cynthia K. Thompson |
| author_sort | Swathi Kiran |
| collection | DOAJ |
| description | Researchers have sought to understand how language is processed in the brain, how brain damage affects language abilities, and what can be expected during the recovery period since the early 19th century. In this review, we first discuss mechanisms of damage and plasticity in the post-stroke brain, both in the acute and the chronic phase of recovery. We then review factors that are associated with recovery. First, we review organism intrinsic variables such as age, lesion volume and location and structural integrity that influence language recovery. Next, we review organism extrinsic factors such as treatment that influence language recovery. Here, we discuss recent advances in our understanding of language recovery and highlight recent work that emphasizes a network perspective of language recovery. Finally, we propose our interpretation of the principles of neuroplasticity, originally proposed by Kleim and Jones (1) in the context of extant literature in aphasia recovery and rehabilitation. Ultimately, we encourage researchers to propose sophisticated intervention studies that bring us closer to the goal of providing precision treatment for patients with aphasia and a better understanding of the neural mechanisms that underlie successful neuroplasticity. |
| first_indexed | 2024-04-13T01:28:28Z |
| format | Article |
| id | doaj.art-2dffed5b2c004564b95836b3b7ecde83 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T01:28:28Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-2dffed5b2c004564b95836b3b7ecde832022-12-22T03:08:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-04-011010.3389/fneur.2019.00295423206Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future ChallengesSwathi Kiran0Cynthia K. Thompson1Cynthia K. Thompson2Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA, United StatesDepartment of Communication Sciences and Disorders, Northwestern University, Evanston, IL, United StatesDepartment of Neurology, The Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesResearchers have sought to understand how language is processed in the brain, how brain damage affects language abilities, and what can be expected during the recovery period since the early 19th century. In this review, we first discuss mechanisms of damage and plasticity in the post-stroke brain, both in the acute and the chronic phase of recovery. We then review factors that are associated with recovery. First, we review organism intrinsic variables such as age, lesion volume and location and structural integrity that influence language recovery. Next, we review organism extrinsic factors such as treatment that influence language recovery. Here, we discuss recent advances in our understanding of language recovery and highlight recent work that emphasizes a network perspective of language recovery. Finally, we propose our interpretation of the principles of neuroplasticity, originally proposed by Kleim and Jones (1) in the context of extant literature in aphasia recovery and rehabilitation. Ultimately, we encourage researchers to propose sophisticated intervention studies that bring us closer to the goal of providing precision treatment for patients with aphasia and a better understanding of the neural mechanisms that underlie successful neuroplasticity.https://www.frontiersin.org/article/10.3389/fneur.2019.00295/fullstrokeaphasianeuroimaging (anatomic and functional)plasticityrecovery |
| spellingShingle | Swathi Kiran Cynthia K. Thompson Cynthia K. Thompson Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges Frontiers in Neurology stroke aphasia neuroimaging (anatomic and functional) plasticity recovery |
| title | Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges |
| title_full | Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges |
| title_fullStr | Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges |
| title_full_unstemmed | Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges |
| title_short | Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges |
| title_sort | neuroplasticity of language networks in aphasia advances updates and future challenges |
| topic | stroke aphasia neuroimaging (anatomic and functional) plasticity recovery |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00295/full |
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