PAX Genes in Cardiovascular Development
The mammalian heart is a four-chambered organ with systemic and pulmonary circulations to deliver oxygenated blood to the body, and a tightly regulated genetic network exists to shape normal development of the heart and its associated major arteries. A key process during cardiovascular morphogenesis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/7713 |
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| author | Rebecca E. Steele Rachel Sanders Helen M. Phillips Simon D. Bamforth |
| author_facet | Rebecca E. Steele Rachel Sanders Helen M. Phillips Simon D. Bamforth |
| author_sort | Rebecca E. Steele |
| collection | DOAJ |
| description | The mammalian heart is a four-chambered organ with systemic and pulmonary circulations to deliver oxygenated blood to the body, and a tightly regulated genetic network exists to shape normal development of the heart and its associated major arteries. A key process during cardiovascular morphogenesis is the septation of the outflow tract which initially forms as a single vessel before separating into the aorta and pulmonary trunk. The outflow tract connects to the aortic arch arteries which are derived from the pharyngeal arch arteries. Congenital heart defects are a major cause of death and morbidity and are frequently associated with a failure to deliver oxygenated blood to the body. The <i>Pax</i> transcription factor family is characterised through their highly conserved paired box and DNA binding domains and are crucial in organogenesis, regulating the development of a wide range of cells, organs and tissues including the cardiovascular system. Studies altering the expression of these genes in murine models, notably <i>Pax3</i> and <i>Pax9,</i> have found a range of cardiovascular patterning abnormalities such as interruption of the aortic arch and common arterial trunk. This suggests that these <i>Pax</i> genes play a crucial role in the regulatory networks governing cardiovascular development. |
| first_indexed | 2024-03-09T10:17:08Z |
| format | Article |
| id | doaj.art-2e001d57994240f48b8e69774303aeaf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:17:08Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2e001d57994240f48b8e69774303aeaf2023-12-01T22:14:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314771310.3390/ijms23147713PAX Genes in Cardiovascular DevelopmentRebecca E. Steele0Rachel Sanders1Helen M. Phillips2Simon D. Bamforth3Bioscience Institute, Faculty of Medical Sciences, Newcastle University, Centre for Life, Newcastle NE1 3BZ, UKBioscience Institute, Faculty of Medical Sciences, Newcastle University, Centre for Life, Newcastle NE1 3BZ, UKBioscience Institute, Faculty of Medical Sciences, Newcastle University, Centre for Life, Newcastle NE1 3BZ, UKBioscience Institute, Faculty of Medical Sciences, Newcastle University, Centre for Life, Newcastle NE1 3BZ, UKThe mammalian heart is a four-chambered organ with systemic and pulmonary circulations to deliver oxygenated blood to the body, and a tightly regulated genetic network exists to shape normal development of the heart and its associated major arteries. A key process during cardiovascular morphogenesis is the septation of the outflow tract which initially forms as a single vessel before separating into the aorta and pulmonary trunk. The outflow tract connects to the aortic arch arteries which are derived from the pharyngeal arch arteries. Congenital heart defects are a major cause of death and morbidity and are frequently associated with a failure to deliver oxygenated blood to the body. The <i>Pax</i> transcription factor family is characterised through their highly conserved paired box and DNA binding domains and are crucial in organogenesis, regulating the development of a wide range of cells, organs and tissues including the cardiovascular system. Studies altering the expression of these genes in murine models, notably <i>Pax3</i> and <i>Pax9,</i> have found a range of cardiovascular patterning abnormalities such as interruption of the aortic arch and common arterial trunk. This suggests that these <i>Pax</i> genes play a crucial role in the regulatory networks governing cardiovascular development.https://www.mdpi.com/1422-0067/23/14/7713<i>Pax3</i><i>Pax9</i>cardiovascular development |
| spellingShingle | Rebecca E. Steele Rachel Sanders Helen M. Phillips Simon D. Bamforth PAX Genes in Cardiovascular Development International Journal of Molecular Sciences <i>Pax3</i> <i>Pax9</i> cardiovascular development |
| title | PAX Genes in Cardiovascular Development |
| title_full | PAX Genes in Cardiovascular Development |
| title_fullStr | PAX Genes in Cardiovascular Development |
| title_full_unstemmed | PAX Genes in Cardiovascular Development |
| title_short | PAX Genes in Cardiovascular Development |
| title_sort | pax genes in cardiovascular development |
| topic | <i>Pax3</i> <i>Pax9</i> cardiovascular development |
| url | https://www.mdpi.com/1422-0067/23/14/7713 |
| work_keys_str_mv | AT rebeccaesteele paxgenesincardiovasculardevelopment AT rachelsanders paxgenesincardiovasculardevelopment AT helenmphillips paxgenesincardiovasculardevelopment AT simondbamforth paxgenesincardiovasculardevelopment |