Met is required for oligodendrocyte progenitor cell migration in <i>Danio rerio</i>
AbstractDuring vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2021-07-01
|
| Series: | G3: Genes, Genomes, Genetics |
| Online Access: | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab265 |
| _version_ | 1818898650042990592 |
|---|---|
| author | Maria F Ali Andrew J Latimer Yinxue Wang Leah Hogenmiller Laura Fontenas Adam J Isabella Cecilia B Moens Guoqiang Yu Sarah Kucenas |
| author_facet | Maria F Ali Andrew J Latimer Yinxue Wang Leah Hogenmiller Laura Fontenas Adam J Isabella Cecilia B Moens Guoqiang Yu Sarah Kucenas |
| author_sort | Maria F Ali |
| collection | DOAJ |
| description | AbstractDuring vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC migration is well characterized, the nature of the molecular mediators that govern it remain largely unknown. Here, using zebrafish as a model, we demonstrate that Met signaling is required for initial developmental migration of OPCs, and, using cell-specific knock-down of Met signaling, show that Met acts cell-autonomously in OPCs. Taken together, these findings demonstrate in vivo |
| first_indexed | 2024-12-19T19:35:26Z |
| format | Article |
| id | doaj.art-2e012e348f1e4726a8687bbec16b7761 |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-12-19T19:35:26Z |
| publishDate | 2021-07-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-2e012e348f1e4726a8687bbec16b77612022-12-21T20:08:29ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362021-07-01111010.1093/g3journal/jkab265Met is required for oligodendrocyte progenitor cell migration in <i>Danio rerio</i>Maria F Ali0Andrew J Latimer1Yinxue Wang2Leah Hogenmiller3Laura Fontenas4Adam J Isabella5Cecilia B Moens6https://orcid.org/0000-0002-1099-0728Guoqiang Yu7https://orcid.org/0000-0002-6743-7413Sarah Kucenas8https://orcid.org/0000-0002-1950-751XDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USADepartment of Biology, University of Virginia, Charlottesville, VA 22904, USADepartment of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USADepartment of Biology, University of Virginia, Charlottesville, VA 22904, USADepartment of Biology, University of Virginia, Charlottesville, VA 22904, USADivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USADivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USADepartment of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USADepartment of Biology, University of Virginia, Charlottesville, VA 22904, USAAbstractDuring vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC migration is well characterized, the nature of the molecular mediators that govern it remain largely unknown. Here, using zebrafish as a model, we demonstrate that Met signaling is required for initial developmental migration of OPCs, and, using cell-specific knock-down of Met signaling, show that Met acts cell-autonomously in OPCs. Taken together, these findings demonstrate in vivohttps://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab265 |
| spellingShingle | Maria F Ali Andrew J Latimer Yinxue Wang Leah Hogenmiller Laura Fontenas Adam J Isabella Cecilia B Moens Guoqiang Yu Sarah Kucenas Met is required for oligodendrocyte progenitor cell migration in <i>Danio rerio</i> G3: Genes, Genomes, Genetics |
| title | Met is required for oligodendrocyte progenitor cell migration in <i>Danio rerio</i> |
| title_full | Met is required for oligodendrocyte progenitor cell migration in <i>Danio rerio</i> |
| title_fullStr | Met is required for oligodendrocyte progenitor cell migration in <i>Danio rerio</i> |
| title_full_unstemmed | Met is required for oligodendrocyte progenitor cell migration in <i>Danio rerio</i> |
| title_short | Met is required for oligodendrocyte progenitor cell migration in <i>Danio rerio</i> |
| title_sort | met is required for oligodendrocyte progenitor cell migration in i danio rerio i |
| url | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab265 |
| work_keys_str_mv | AT mariafali metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi AT andrewjlatimer metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi AT yinxuewang metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi AT leahhogenmiller metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi AT laurafontenas metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi AT adamjisabella metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi AT ceciliabmoens metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi AT guoqiangyu metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi AT sarahkucenas metisrequiredforoligodendrocyteprogenitorcellmigrationinidaniorerioi |