Characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization-related symptoms
Abstract Central sensitization-related symptoms (CSS) are associated with the severity and progression of pain. The relationship between the severity of pain/CSS and clinical progresses remains unclear. This multicenter, collaborative, longitudinal study aimed to characterize the clinical outcomes o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55290-4 |
| _version_ | 1797274991038824448 |
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| author | Hayato Shigetoh Masayuki Koga Yoichi Tanaka Yoshiyuki Hirakawa Shu Morioka |
| author_facet | Hayato Shigetoh Masayuki Koga Yoichi Tanaka Yoshiyuki Hirakawa Shu Morioka |
| author_sort | Hayato Shigetoh |
| collection | DOAJ |
| description | Abstract Central sensitization-related symptoms (CSS) are associated with the severity and progression of pain. The relationship between the severity of pain/CSS and clinical progresses remains unclear. This multicenter, collaborative, longitudinal study aimed to characterize the clinical outcomes of patients with musculoskeletal pain by classifying subgroups based on the severity of pain/CSS and examining changes in subgroups over time. We measured the pain intensity, CSS, catastrophic thinking, and body perception disturbance in 435 patients with musculoskeletal pain. Reevaluation of patients after one month included 166 patients for pain intensity outcome and 110 for both pain intensity and CSS outcome analysis. We classified the patients into four groups (mild pain/CSS, severe pain/mild CSS, severe pain/CSS, and mild pain/severe CSS groups) and performed multiple comparison analyses to reveal the differences between the CSS severity groups. Additionally, we performed the adjusted residual chi-square to identify the number of patients with pain improvement, group transition, changing pain, and CSS pattern groups at baseline. The most characteristic result was that the mild and severe CSS groups showed worsening pain. Moreover, many of the group transitions were to the same group, with a few transitioning to a group with mild pain/CSS. Our findings suggest that the severity and improvement of CSS influence pain prognosis. |
| first_indexed | 2024-03-07T15:07:00Z |
| format | Article |
| id | doaj.art-2e026594b052403698751a3d477ee448 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:07:00Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2e026594b052403698751a3d477ee4482024-03-05T18:50:08ZengNature PortfolioScientific Reports2045-23222024-02-011411710.1038/s41598-024-55290-4Characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization-related symptomsHayato Shigetoh0Masayuki Koga1Yoichi Tanaka2Yoshiyuki Hirakawa3Shu Morioka4Department of Physical Therapy, Faculty of Health Science, Kyoto Tachibana UniversityDepartment of Neurorehabilitation, Graduate School of Health Sciences, Kio UniversityNeurorehabilitation Research Center, Kio UniversityNeurorehabilitation Research Center, Kio UniversityNeurorehabilitation Research Center, Kio UniversityAbstract Central sensitization-related symptoms (CSS) are associated with the severity and progression of pain. The relationship between the severity of pain/CSS and clinical progresses remains unclear. This multicenter, collaborative, longitudinal study aimed to characterize the clinical outcomes of patients with musculoskeletal pain by classifying subgroups based on the severity of pain/CSS and examining changes in subgroups over time. We measured the pain intensity, CSS, catastrophic thinking, and body perception disturbance in 435 patients with musculoskeletal pain. Reevaluation of patients after one month included 166 patients for pain intensity outcome and 110 for both pain intensity and CSS outcome analysis. We classified the patients into four groups (mild pain/CSS, severe pain/mild CSS, severe pain/CSS, and mild pain/severe CSS groups) and performed multiple comparison analyses to reveal the differences between the CSS severity groups. Additionally, we performed the adjusted residual chi-square to identify the number of patients with pain improvement, group transition, changing pain, and CSS pattern groups at baseline. The most characteristic result was that the mild and severe CSS groups showed worsening pain. Moreover, many of the group transitions were to the same group, with a few transitioning to a group with mild pain/CSS. Our findings suggest that the severity and improvement of CSS influence pain prognosis.https://doi.org/10.1038/s41598-024-55290-4PainCentral sensitization-related symptomsProgress |
| spellingShingle | Hayato Shigetoh Masayuki Koga Yoichi Tanaka Yoshiyuki Hirakawa Shu Morioka Characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization-related symptoms Scientific Reports Pain Central sensitization-related symptoms Progress |
| title | Characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization-related symptoms |
| title_full | Characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization-related symptoms |
| title_fullStr | Characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization-related symptoms |
| title_full_unstemmed | Characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization-related symptoms |
| title_short | Characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization-related symptoms |
| title_sort | characterizing clinical progression in patients with musculoskeletal pain by pain severity and central sensitization related symptoms |
| topic | Pain Central sensitization-related symptoms Progress |
| url | https://doi.org/10.1038/s41598-024-55290-4 |
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