The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents
Abstract Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospec...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92463-x |
| _version_ | 1818736743818461184 |
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| author | Joanna Bartkowiak Ernest Spitzer Reto Kurmann Fabian Zürcher Peter Krähenmann Victoria Garcia-Ruiz Jorge Mercado Christoph Ryffel Sylvain Losdat Nassip Llerena Pedro Torres Jonas Lanz Martin Stocker Ben Ren Martin Glöckler Thomas Pilgrim |
| author_facet | Joanna Bartkowiak Ernest Spitzer Reto Kurmann Fabian Zürcher Peter Krähenmann Victoria Garcia-Ruiz Jorge Mercado Christoph Ryffel Sylvain Losdat Nassip Llerena Pedro Torres Jonas Lanz Martin Stocker Ben Ren Martin Glöckler Thomas Pilgrim |
| author_sort | Joanna Bartkowiak |
| collection | DOAJ |
| description | Abstract Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospectively collected cross-sectional data of children between 5 and 16 years of age from randomly selected schools in Peru, parameters of LV geometry and function were compared according to presence or absence of obesity (body mass index z-score > 2). LVH was based on left ventricular mass index (LVMI) adjusted for age and sex and defined by a z-score of > 2. LV diastolic function was assessed using mitral inflow early-to-late diastolic flow (E/A) ratio, peak early diastolic tissue velocities of the lateral mitral annulus (E′), early diastolic transmitral flow velocity to tissue Doppler mitral annular early diastolic velocity (E/E′) ratio, and left atrial volume index (LAVI). Among 1023 children, 681 children (mean age 12.2 ± 3.1 years, 341 male (50.1%)) were available for the present analysis, of which 150 (22.0%) were obese. LVH was found in 21 (14.0%) obese and in 19 (3.6%) non-obese children (padjusted < 0.001). LVMI was greater in obese than that in non-obese children (36.1 ± 8.6 versus 28.7 ± 6.9 g/m2.7, p < 0.001). The mean mitral E/E′ ratio and LAVI were significantly higher in obese than those in non-obese individuals (E/E′: 5.2 ± 1.1 versus 4.9 ± 0.8, padjusted = 0.043; LAVI 11.0 ± 3.2 versus 9.6 ± 2.9, padjusted = 0.001), whereas E′ and E/A ratio were comparable. Childhood obesity was associated with left ventricular hypertrophy and determinants of diastolic dysfunction. ClinicalTrials.gov Identifier: NCT02353663. |
| first_indexed | 2024-12-18T00:42:00Z |
| format | Article |
| id | doaj.art-2e029b1523ed4a2c9ce2217401082a8f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T00:42:00Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2e029b1523ed4a2c9ce2217401082a8f2022-12-21T21:26:52ZengNature PortfolioScientific Reports2045-23222021-06-011111810.1038/s41598-021-92463-xThe impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescentsJoanna Bartkowiak0Ernest Spitzer1Reto Kurmann2Fabian Zürcher3Peter Krähenmann4Victoria Garcia-Ruiz5Jorge Mercado6Christoph Ryffel7Sylvain Losdat8Nassip Llerena9Pedro Torres10Jonas Lanz11Martin Stocker12Ben Ren13Martin Glöckler14Thomas Pilgrim15Department of Cardiology, Inselspital, Bern University Hospital, University of BernCardialysisDepartment of Cardiology, Cantonal Hospital LucerneDepartment of Cardiology, Inselspital, Bern University Hospital, University of BernDepartment of Cardiology, Cantonal Hospital St. GallenCardialysisInstitute of Cardiology CardioSaludDepartment of Cardiology, Inselspital, Bern University Hospital, University of BernCTU Bern, University of BernNational Hospital Carlos Alberto Seguín EscobedoInstitute of Cardiology CardioSaludDepartment of Cardiology, Inselspital, Bern University Hospital, University of BernDepartment of Cardiology, Cantonal Hospital LucerneCardialysisDepartment of Pediatric Cardiology, Inselspital, University of BernDepartment of Cardiology, Inselspital, Bern University Hospital, University of BernAbstract Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospectively collected cross-sectional data of children between 5 and 16 years of age from randomly selected schools in Peru, parameters of LV geometry and function were compared according to presence or absence of obesity (body mass index z-score > 2). LVH was based on left ventricular mass index (LVMI) adjusted for age and sex and defined by a z-score of > 2. LV diastolic function was assessed using mitral inflow early-to-late diastolic flow (E/A) ratio, peak early diastolic tissue velocities of the lateral mitral annulus (E′), early diastolic transmitral flow velocity to tissue Doppler mitral annular early diastolic velocity (E/E′) ratio, and left atrial volume index (LAVI). Among 1023 children, 681 children (mean age 12.2 ± 3.1 years, 341 male (50.1%)) were available for the present analysis, of which 150 (22.0%) were obese. LVH was found in 21 (14.0%) obese and in 19 (3.6%) non-obese children (padjusted < 0.001). LVMI was greater in obese than that in non-obese children (36.1 ± 8.6 versus 28.7 ± 6.9 g/m2.7, p < 0.001). The mean mitral E/E′ ratio and LAVI were significantly higher in obese than those in non-obese individuals (E/E′: 5.2 ± 1.1 versus 4.9 ± 0.8, padjusted = 0.043; LAVI 11.0 ± 3.2 versus 9.6 ± 2.9, padjusted = 0.001), whereas E′ and E/A ratio were comparable. Childhood obesity was associated with left ventricular hypertrophy and determinants of diastolic dysfunction. ClinicalTrials.gov Identifier: NCT02353663.https://doi.org/10.1038/s41598-021-92463-x |
| spellingShingle | Joanna Bartkowiak Ernest Spitzer Reto Kurmann Fabian Zürcher Peter Krähenmann Victoria Garcia-Ruiz Jorge Mercado Christoph Ryffel Sylvain Losdat Nassip Llerena Pedro Torres Jonas Lanz Martin Stocker Ben Ren Martin Glöckler Thomas Pilgrim The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents Scientific Reports |
| title | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
| title_full | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
| title_fullStr | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
| title_full_unstemmed | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
| title_short | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
| title_sort | impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
| url | https://doi.org/10.1038/s41598-021-92463-x |
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