Primary HSV-2 Infection in Early Pregnancy Results in Transplacental Viral Transmission and Dose-Dependent Adverse Pregnancy Outcomes in a Novel Mouse Model

Primary HSV-2 Infection in Early Pregnancy Results in Transplacental Viral Transmission and Dose-Dependent Adverse Pregnancy Outcomes in a Novel Mouse Model

Herpes simplex virus type 2 (HSV-2) infection affects 24 million births annually and is associated with adverse pregnancy outcomes, including neonatal herpes; however, the mechanisms underlying in utero transmission of HSV-2 are largely unknown. We examined the effects of primary HSV-2 infection dur...

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Bibliographic Details
Main Authors: Allison M. Felker, Philip Nguyen, Charu Kaushic
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
HSV-2
viral infection
pregnancy
placental pathology
neonatal herpes
mouse model
Online Access:https://www.mdpi.com/1999-4915/13/10/1929

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