Prepulse Inhibition in Cocaine Addiction and Dual Pathologies
Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated PPI and the phenotype o...
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MDPI AG
2021-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/2/269 |
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| author | Isis Gil-Miravet Alejandro Fuertes-Saiz Ana Benito Isabel Almodóvar Enrique Ochoa Gonzalo Haro |
| author_facet | Isis Gil-Miravet Alejandro Fuertes-Saiz Ana Benito Isabel Almodóvar Enrique Ochoa Gonzalo Haro |
| author_sort | Isis Gil-Miravet |
| collection | DOAJ |
| description | Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated PPI and the phenotype of patients with cocaine-related disorder (CRD) who presented a dual diagnosis of schizophrenia or antisocial personality disorder. A total of 74 men aged 18–60 years were recruited for this research. The sample was divided into four groups: CRD (<i>n</i> = 14), CRD and schizophrenia (<i>n</i> = 21), CRD and antisocial personality disorder (<i>n</i> = 16), and a control group (<i>n</i> = 23). We evaluated the PPI and other possible vulnerability factors in these patients by using different assessment scales. PPI was higher in the CRD group at 30 ms (F(3, 64) = 2.972, <i>p</i> = 0.038). Three discriminant functions were obtained which allowed us to use the overall Hare Psychopathy Checklist Revised score, reward sensitivity, and PPI at 30 ms to predict inclusion of these patients in the different groups with a success rate of 79.7% (42.9% for CRD, 76.2% for CRD and schizophrenia, 100% for CRD and antisocial personality disorder, and 91.3% in the control group). Despite the differences we observed in PPI, this factor is of little use for discriminating between the different diagnostic groups and it acts more as a non-specific endophenotype in certain mental disorders, such as in patients with a dual diagnosis. |
| first_indexed | 2024-03-09T00:41:25Z |
| format | Article |
| id | doaj.art-2e03943d11954961a57342c0dd065d86 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T00:41:25Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-2e03943d11954961a57342c0dd065d862023-12-11T17:48:29ZengMDPI AGBrain Sciences2076-34252021-02-0111226910.3390/brainsci11020269Prepulse Inhibition in Cocaine Addiction and Dual PathologiesIsis Gil-Miravet0Alejandro Fuertes-Saiz1Ana Benito2Isabel Almodóvar3Enrique Ochoa4Gonzalo Haro5TXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castellón, SpainTXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castellón, SpainTXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castellón, SpainTXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castellón, SpainMolecular Biopathology Department, Consorcio Hospitalario Provincial de Castellón, 12002 Castellón, SpainTXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castellón, SpainCocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated PPI and the phenotype of patients with cocaine-related disorder (CRD) who presented a dual diagnosis of schizophrenia or antisocial personality disorder. A total of 74 men aged 18–60 years were recruited for this research. The sample was divided into four groups: CRD (<i>n</i> = 14), CRD and schizophrenia (<i>n</i> = 21), CRD and antisocial personality disorder (<i>n</i> = 16), and a control group (<i>n</i> = 23). We evaluated the PPI and other possible vulnerability factors in these patients by using different assessment scales. PPI was higher in the CRD group at 30 ms (F(3, 64) = 2.972, <i>p</i> = 0.038). Three discriminant functions were obtained which allowed us to use the overall Hare Psychopathy Checklist Revised score, reward sensitivity, and PPI at 30 ms to predict inclusion of these patients in the different groups with a success rate of 79.7% (42.9% for CRD, 76.2% for CRD and schizophrenia, 100% for CRD and antisocial personality disorder, and 91.3% in the control group). Despite the differences we observed in PPI, this factor is of little use for discriminating between the different diagnostic groups and it acts more as a non-specific endophenotype in certain mental disorders, such as in patients with a dual diagnosis.https://www.mdpi.com/2076-3425/11/2/269dual diagnosisschizophreniaantisocial personality disordercocaine-related disorderpsychopathyprepulse inhibition |
| spellingShingle | Isis Gil-Miravet Alejandro Fuertes-Saiz Ana Benito Isabel Almodóvar Enrique Ochoa Gonzalo Haro Prepulse Inhibition in Cocaine Addiction and Dual Pathologies Brain Sciences dual diagnosis schizophrenia antisocial personality disorder cocaine-related disorder psychopathy prepulse inhibition |
| title | Prepulse Inhibition in Cocaine Addiction and Dual Pathologies |
| title_full | Prepulse Inhibition in Cocaine Addiction and Dual Pathologies |
| title_fullStr | Prepulse Inhibition in Cocaine Addiction and Dual Pathologies |
| title_full_unstemmed | Prepulse Inhibition in Cocaine Addiction and Dual Pathologies |
| title_short | Prepulse Inhibition in Cocaine Addiction and Dual Pathologies |
| title_sort | prepulse inhibition in cocaine addiction and dual pathologies |
| topic | dual diagnosis schizophrenia antisocial personality disorder cocaine-related disorder psychopathy prepulse inhibition |
| url | https://www.mdpi.com/2076-3425/11/2/269 |
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