Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review
Diabetic foot ulcers (DFUs) pose a significant threat to individuals with diabetes mellitus (DM), such as lower limb amputation and severe morbidity. Bioengineered skin substitutes (BSS) are alternatives to traditional interventions for treating DFUs, but their efficacy compared to standard wound ca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1221 |
| _version_ | 1797264281147801600 |
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| author | Nathaniel R. Primous Peter T. Elvin Kathleen V. Carter Hagner L. Andrade Javier La Fontaine Naohiro Shibuya Claudia C. Biguetti |
| author_facet | Nathaniel R. Primous Peter T. Elvin Kathleen V. Carter Hagner L. Andrade Javier La Fontaine Naohiro Shibuya Claudia C. Biguetti |
| author_sort | Nathaniel R. Primous |
| collection | DOAJ |
| description | Diabetic foot ulcers (DFUs) pose a significant threat to individuals with diabetes mellitus (DM), such as lower limb amputation and severe morbidity. Bioengineered skin substitutes (BSS) are alternatives to traditional interventions for treating DFUs, but their efficacy compared to standard wound care (SWC) or other treatment types, such as allografts, remains unknown. A scoping review of human studies was conducted to identify current approaches in the treatment of DFUs using BSS as compared with other treatment options. Systematic searches in PubMed, Cochrane Library, and Web of Science were conducted to identify comparative studies that enrolled 10 or more patients and evaluated wound healing outcomes (closure, time-to-healing, and area reduction). Database searches isolated articles published from 1 December 2012 to 1 December 2022 and were conducted in accordance with PRISMA-ScR guidelines. The literature search yielded 1312 articles, 24 of which were included for the qualitative analysis. Findings in these studies demonstrated that BSS outperformed SWC in all measured outcomes, suggesting that BSS may be a superior treatment for DFUs. Of the 24 articles, 8 articles compared human amniotic membrane allografts (hAMA) to BSS. Conflicting evidence was observed when comparing BSS and hAMA treatments, highlighting the need for future research. |
| first_indexed | 2024-04-25T00:26:24Z |
| format | Article |
| id | doaj.art-2e05e7d34b6a4a919301e4bab320e859 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:24Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2e05e7d34b6a4a919301e4bab320e8592024-03-12T16:47:36ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135122110.3390/jcm13051221Bioengineered Skin for Diabetic Foot Ulcers: A Scoping ReviewNathaniel R. Primous0Peter T. Elvin1Kathleen V. Carter2Hagner L. Andrade3Javier La Fontaine4Naohiro Shibuya5Claudia C. Biguetti6Department of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USADepartment of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USALibrary, School of Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USADepartment of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USADepartment of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USADepartment of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USADepartment of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USADiabetic foot ulcers (DFUs) pose a significant threat to individuals with diabetes mellitus (DM), such as lower limb amputation and severe morbidity. Bioengineered skin substitutes (BSS) are alternatives to traditional interventions for treating DFUs, but their efficacy compared to standard wound care (SWC) or other treatment types, such as allografts, remains unknown. A scoping review of human studies was conducted to identify current approaches in the treatment of DFUs using BSS as compared with other treatment options. Systematic searches in PubMed, Cochrane Library, and Web of Science were conducted to identify comparative studies that enrolled 10 or more patients and evaluated wound healing outcomes (closure, time-to-healing, and area reduction). Database searches isolated articles published from 1 December 2012 to 1 December 2022 and were conducted in accordance with PRISMA-ScR guidelines. The literature search yielded 1312 articles, 24 of which were included for the qualitative analysis. Findings in these studies demonstrated that BSS outperformed SWC in all measured outcomes, suggesting that BSS may be a superior treatment for DFUs. Of the 24 articles, 8 articles compared human amniotic membrane allografts (hAMA) to BSS. Conflicting evidence was observed when comparing BSS and hAMA treatments, highlighting the need for future research.https://www.mdpi.com/2077-0383/13/5/1221tissue engineeringdiabetic foot ulcersbioengineered tissues and organschronic woundtissue regenerationbioengineered skin |
| spellingShingle | Nathaniel R. Primous Peter T. Elvin Kathleen V. Carter Hagner L. Andrade Javier La Fontaine Naohiro Shibuya Claudia C. Biguetti Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review Journal of Clinical Medicine tissue engineering diabetic foot ulcers bioengineered tissues and organs chronic wound tissue regeneration bioengineered skin |
| title | Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review |
| title_full | Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review |
| title_fullStr | Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review |
| title_full_unstemmed | Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review |
| title_short | Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review |
| title_sort | bioengineered skin for diabetic foot ulcers a scoping review |
| topic | tissue engineering diabetic foot ulcers bioengineered tissues and organs chronic wound tissue regeneration bioengineered skin |
| url | https://www.mdpi.com/2077-0383/13/5/1221 |
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