Lamotrigine-Loaded Poloxamer-Based Thermo-Responsive Sol–Gel: Formulation, In Vitro Assessment, Ex Vivo Permeation, and Toxicology Study

Lamotrigine-Loaded Poloxamer-Based Thermo-Responsive Sol–Gel: Formulation, In Vitro Assessment, Ex Vivo Permeation, and Toxicology Study

The present study aimed to prepare, characterize, and evaluate a thermo-responsive sol–gel for intranasal delivery of lamotrigine (LTG), which was designed for sustained drug delivery to treat epilepsy. LTG sol–gel was prepared using the cold method by changing the concentrations of poloxamer 407 an...

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Bibliographic Details
Main Authors: Maria Riaz, Muhammad Zaman, Huma Hameed, Hafiz Shoaib Sarwar, Mahtab Ahmad Khan, Ali Irfan, Gamal A. Shazly, Ana Cláudia Paiva-Santos, Yousef A. Bin Jardan
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Gels
Subjects:
lamotrigine
epilepsy
poloxamer 407
nose to brain
intranasal
Online Access:https://www.mdpi.com/2310-2861/9/10/817

Internet

https://www.mdpi.com/2310-2861/9/10/817

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