Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity is ensured by HSET-mediated spindle pole clust...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15803 |
| _version_ | 1818422799399649280 |
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| author | Menuka Karki Neda Keyhaninejad Charles B. Shuster |
| author_facet | Menuka Karki Neda Keyhaninejad Charles B. Shuster |
| author_sort | Menuka Karki |
| collection | DOAJ |
| description | The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity is ensured by HSET-mediated spindle pole clustering. |
| first_indexed | 2024-12-14T13:32:00Z |
| format | Article |
| id | doaj.art-2e0996f0790f44e394e9f142b8319d0d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:32:00Z |
| publishDate | 2017-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2e0996f0790f44e394e9f142b8319d0d2022-12-21T22:59:40ZengNature PortfolioNature Communications2041-17232017-06-018111210.1038/ncomms15803Precocious centriole disengagement and centrosome fragmentation induced by mitotic delayMenuka Karki0Neda Keyhaninejad1Charles B. Shuster2Department of Biology, New Mexico State UniversityDepartment of Biology, New Mexico State UniversityDepartment of Biology, New Mexico State UniversityThe spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity is ensured by HSET-mediated spindle pole clustering.https://doi.org/10.1038/ncomms15803 |
| spellingShingle | Menuka Karki Neda Keyhaninejad Charles B. Shuster Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay Nature Communications |
| title | Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay |
| title_full | Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay |
| title_fullStr | Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay |
| title_full_unstemmed | Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay |
| title_short | Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay |
| title_sort | precocious centriole disengagement and centrosome fragmentation induced by mitotic delay |
| url | https://doi.org/10.1038/ncomms15803 |
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