Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules
An expedient regioselectivesynthesis of novel mono, C2-symmetric bis-triazole and acridinedione bridged macromolecules has been achieved in good yields employing intermolecular Cu(I) catalyzed azide and alkyne click reaction. Synthesis of O-propargyl acridinedione was achieved in three good yielding...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610320301332 |
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| author | Rajesh Raju Shanmugam Rajasekar Raghavachary Raghunathan Natarajan Arumugam Abdulrahman I. Almansour Raju Suresh Kumar |
| author_facet | Rajesh Raju Shanmugam Rajasekar Raghavachary Raghunathan Natarajan Arumugam Abdulrahman I. Almansour Raju Suresh Kumar |
| author_sort | Rajesh Raju |
| collection | DOAJ |
| description | An expedient regioselectivesynthesis of novel mono, C2-symmetric bis-triazole and acridinedione bridged macromolecules has been achieved in good yields employing intermolecular Cu(I) catalyzed azide and alkyne click reaction. Synthesis of O-propargyl acridinedione was achieved in three good yielding steps starting from dimedone, while the symmetrical aliphatic and aryl bis-azides were derived from appropriate dibromides in the presence of sodium azide in dry DMF. The synthesized mono and C2-symmetric bis-macromolecules have been elucidated by 1H, 13C, elemental and mass spectroscopic analysis. The antioxidant activity of synthesized compounds has also been investigated. |
| first_indexed | 2024-12-13T21:56:13Z |
| format | Article |
| id | doaj.art-2e0aafbede1e48caa62f122144ce7669 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-13T21:56:13Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-2e0aafbede1e48caa62f122144ce76692022-12-21T23:30:07ZengElsevierJournal of Saudi Chemical Society1319-61032020-12-012412934941Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromoleculesRajesh Raju0Shanmugam Rajasekar1Raghavachary Raghunathan2Natarajan Arumugam3Abdulrahman I. Almansour4Raju Suresh Kumar5Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India; Corresponding authors at: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India.Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, IndiaDepartment of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India; Corresponding authors at: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India.Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaAn expedient regioselectivesynthesis of novel mono, C2-symmetric bis-triazole and acridinedione bridged macromolecules has been achieved in good yields employing intermolecular Cu(I) catalyzed azide and alkyne click reaction. Synthesis of O-propargyl acridinedione was achieved in three good yielding steps starting from dimedone, while the symmetrical aliphatic and aryl bis-azides were derived from appropriate dibromides in the presence of sodium azide in dry DMF. The synthesized mono and C2-symmetric bis-macromolecules have been elucidated by 1H, 13C, elemental and mass spectroscopic analysis. The antioxidant activity of synthesized compounds has also been investigated.http://www.sciencedirect.com/science/article/pii/S1319610320301332Acridinedione1,2,3-TriazoleMacromoleculesAzideClick Chemistry reactionAntioxidant activity |
| spellingShingle | Rajesh Raju Shanmugam Rajasekar Raghavachary Raghunathan Natarajan Arumugam Abdulrahman I. Almansour Raju Suresh Kumar Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules Journal of Saudi Chemical Society Acridinedione 1,2,3-Triazole Macromolecules Azide Click Chemistry reaction Antioxidant activity |
| title | Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules |
| title_full | Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules |
| title_fullStr | Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules |
| title_full_unstemmed | Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules |
| title_short | Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules |
| title_sort | regioselective synthesis and antioxidant activity of a novel class of mono and c2 symmetric bis 1 2 3 triazole and acridinedione grafted macromolecules |
| topic | Acridinedione 1,2,3-Triazole Macromolecules Azide Click Chemistry reaction Antioxidant activity |
| url | http://www.sciencedirect.com/science/article/pii/S1319610320301332 |
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