Chiral Analysis of Pesticides and Drugs of Environmental Concern: Biodegradation and Enantiomeric Fraction
The importance of stereochemistry for medicinal chemistry and pharmacology is well recognized and the dissimilar behavior of enantiomers is fully documented. Regarding the environment, the significance is equivalent since enantiomers of chiral organic pollutants can also differ in biodegradation pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Symmetry |
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| Online Access: | https://www.mdpi.com/2073-8994/9/9/196 |
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| author | Alexandra S. Maia Ana R. Ribeiro Paula M. L. Castro Maria Elizabeth Tiritan |
| author_facet | Alexandra S. Maia Ana R. Ribeiro Paula M. L. Castro Maria Elizabeth Tiritan |
| author_sort | Alexandra S. Maia |
| collection | DOAJ |
| description | The importance of stereochemistry for medicinal chemistry and pharmacology is well recognized and the dissimilar behavior of enantiomers is fully documented. Regarding the environment, the significance is equivalent since enantiomers of chiral organic pollutants can also differ in biodegradation processes and fate, as well as in ecotoxicity. This review comprises designed biodegradation studies of several chiral drugs and pesticides followed by enantioselective analytical methodologies to accurately measure the enantiomeric fraction (EF). The enantioselective monitoring of microcosms and laboratory-scale experiments with different environmental matrices is herein reported. Thus, this review focuses on the importance of evaluating the EF variation during biodegradation studies of chiral pharmaceuticals, drugs of abuse, and agrochemicals and has implications for the understanding of the environmental fate of chiral pollutants. |
| first_indexed | 2024-04-13T08:13:23Z |
| format | Article |
| id | doaj.art-2e0ad1b367ab460a94d7f01f89692a28 |
| institution | Directory Open Access Journal |
| issn | 2073-8994 |
| language | English |
| last_indexed | 2024-04-13T08:13:23Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-2e0ad1b367ab460a94d7f01f89692a282022-12-22T02:54:52ZengMDPI AGSymmetry2073-89942017-09-019919610.3390/sym9090196sym9090196Chiral Analysis of Pesticides and Drugs of Environmental Concern: Biodegradation and Enantiomeric FractionAlexandra S. Maia0Ana R. Ribeiro1Paula M. L. Castro2Maria Elizabeth Tiritan3CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, PortugalLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials (LSRE-LCM), Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, PortugalUniversidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Arquiteto Lobão Vital, apartado 2511, 4202-401 Porto, PortugalCESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, PortugalThe importance of stereochemistry for medicinal chemistry and pharmacology is well recognized and the dissimilar behavior of enantiomers is fully documented. Regarding the environment, the significance is equivalent since enantiomers of chiral organic pollutants can also differ in biodegradation processes and fate, as well as in ecotoxicity. This review comprises designed biodegradation studies of several chiral drugs and pesticides followed by enantioselective analytical methodologies to accurately measure the enantiomeric fraction (EF). The enantioselective monitoring of microcosms and laboratory-scale experiments with different environmental matrices is herein reported. Thus, this review focuses on the importance of evaluating the EF variation during biodegradation studies of chiral pharmaceuticals, drugs of abuse, and agrochemicals and has implications for the understanding of the environmental fate of chiral pollutants.https://www.mdpi.com/2073-8994/9/9/196enantiomeric fraction (EF)enantioselectivitychiral analysisbiodegradationpesticidespharmaceuticals |
| spellingShingle | Alexandra S. Maia Ana R. Ribeiro Paula M. L. Castro Maria Elizabeth Tiritan Chiral Analysis of Pesticides and Drugs of Environmental Concern: Biodegradation and Enantiomeric Fraction Symmetry enantiomeric fraction (EF) enantioselectivity chiral analysis biodegradation pesticides pharmaceuticals |
| title | Chiral Analysis of Pesticides and Drugs of Environmental Concern: Biodegradation and Enantiomeric Fraction |
| title_full | Chiral Analysis of Pesticides and Drugs of Environmental Concern: Biodegradation and Enantiomeric Fraction |
| title_fullStr | Chiral Analysis of Pesticides and Drugs of Environmental Concern: Biodegradation and Enantiomeric Fraction |
| title_full_unstemmed | Chiral Analysis of Pesticides and Drugs of Environmental Concern: Biodegradation and Enantiomeric Fraction |
| title_short | Chiral Analysis of Pesticides and Drugs of Environmental Concern: Biodegradation and Enantiomeric Fraction |
| title_sort | chiral analysis of pesticides and drugs of environmental concern biodegradation and enantiomeric fraction |
| topic | enantiomeric fraction (EF) enantioselectivity chiral analysis biodegradation pesticides pharmaceuticals |
| url | https://www.mdpi.com/2073-8994/9/9/196 |
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