Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT
Introduction:<br/>To examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer‘s disease (AD).<br/><br/>Material and Methods:<br/>This cross-sectional s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00022/full |
| _version_ | 1818288012975407104 |
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| author | Robert eKromer Nermin eSerbecic Lucrezia eHausner Fahmy eAboul-Enein Lutz eFroelich Sven eBeutelspacher |
| author_facet | Robert eKromer Nermin eSerbecic Lucrezia eHausner Fahmy eAboul-Enein Lutz eFroelich Sven eBeutelspacher |
| author_sort | Robert eKromer |
| collection | DOAJ |
| description | Introduction:<br/>To examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer‘s disease (AD).<br/><br/>Material and Methods:<br/>This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fibre layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects.<br/><br/>Results:<br/>Patients with AD showed a significant decrease in RNFL thickness in the nasal superior sector compared to the control group (101.0 ± 18.18 µm vs. 122.8 ± 28.08 µm; p |
| first_indexed | 2024-12-13T01:49:37Z |
| format | Article |
| id | doaj.art-2e0f13a0e5d945d49eb61397f2304e7e |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T01:49:37Z |
| publishDate | 2014-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-2e0f13a0e5d945d49eb61397f2304e7e2022-12-22T00:03:32ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402014-02-01510.3389/fpsyt.2014.0002272623Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCTRobert eKromer0Nermin eSerbecic1Lucrezia eHausner2Fahmy eAboul-Enein3Lutz eFroelich4Sven eBeutelspacher5University of Heidelberg, UMM, Eye HospitalUniversity of Heidelberg, UMM, Eye HospitalCentral Institute of Mental HealthSMZ OST, DONAUSPITALCentral Institute of Mental HealthUniversity of Heidelberg, UMM, Eye HospitalIntroduction:<br/>To examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer‘s disease (AD).<br/><br/>Material and Methods:<br/>This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fibre layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects.<br/><br/>Results:<br/>Patients with AD showed a significant decrease in RNFL thickness in the nasal superior sector compared to the control group (101.0 ± 18.18 µm vs. 122.8 ± 28.08 µm; phttp://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00022/fullDementiaAlzheimerOCTretinal nerve fiber layerRNFLT |
| spellingShingle | Robert eKromer Nermin eSerbecic Lucrezia eHausner Fahmy eAboul-Enein Lutz eFroelich Sven eBeutelspacher Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT Frontiers in Psychiatry Dementia Alzheimer OCT retinal nerve fiber layer RNFLT |
| title | Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT |
| title_full | Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT |
| title_fullStr | Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT |
| title_full_unstemmed | Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT |
| title_short | Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT |
| title_sort | detection of retinal nerve fiber layer defects in alzheimer s disease using sd oct |
| topic | Dementia Alzheimer OCT retinal nerve fiber layer RNFLT |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00022/full |
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