Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population
<p>Abstract</p> <p>Background</p> <p>Various lines of evidence demonstrate the involvement of mitochondrial dysfunction in the pathogenesis of glaucoma. Therefore, mitochondrial DNA is a promising candidate for genetic susceptibility studies on glaucoma. To test the hyp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-01-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/11/8 |
| _version_ | 1818246711610441728 |
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| author | Wissinger Bernd Pasutto Francesca Müller-Myhsok Bertram Gramer Eugen Wolf Christiane Weisschuh Nicole |
| author_facet | Wissinger Bernd Pasutto Francesca Müller-Myhsok Bertram Gramer Eugen Wolf Christiane Weisschuh Nicole |
| author_sort | Wissinger Bernd |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Various lines of evidence demonstrate the involvement of mitochondrial dysfunction in the pathogenesis of glaucoma. Therefore, mitochondrial DNA is a promising candidate for genetic susceptibility studies on glaucoma. To test the hypothesis that mitochondrial haplogroups influence the risk to develop glaucoma, we genotyped 12 single-nucleotide polymorphisms that define the European mitochondrial DNA haplogroups in healthy controls and two German patient cohorts with either exfoliation glaucoma or the normal tension subgroup of primary open angle glaucoma.</p> <p>Results</p> <p>Mitochondrial haplogroup U was significantly under-represented in patients with exfoliation glaucoma (8.3% compared with 18.9% in controls; p = 0.004).</p> <p>Conclusions</p> <p>People with haplogroup U have a lower risk to develop exfoliation glaucoma. Our results substantiate the suggestion that mitochondrial alterations have an impact on the etiology of glaucoma.</p> |
| first_indexed | 2024-12-12T14:53:09Z |
| format | Article |
| id | doaj.art-2e0f7cc2708a4f86b69cf3f310c42168 |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-12-12T14:53:09Z |
| publishDate | 2010-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-2e0f7cc2708a4f86b69cf3f310c421682022-12-22T00:20:58ZengBMCBMC Genetics1471-21562010-01-01111810.1186/1471-2156-11-8Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German populationWissinger BerndPasutto FrancescaMüller-Myhsok BertramGramer EugenWolf ChristianeWeisschuh Nicole<p>Abstract</p> <p>Background</p> <p>Various lines of evidence demonstrate the involvement of mitochondrial dysfunction in the pathogenesis of glaucoma. Therefore, mitochondrial DNA is a promising candidate for genetic susceptibility studies on glaucoma. To test the hypothesis that mitochondrial haplogroups influence the risk to develop glaucoma, we genotyped 12 single-nucleotide polymorphisms that define the European mitochondrial DNA haplogroups in healthy controls and two German patient cohorts with either exfoliation glaucoma or the normal tension subgroup of primary open angle glaucoma.</p> <p>Results</p> <p>Mitochondrial haplogroup U was significantly under-represented in patients with exfoliation glaucoma (8.3% compared with 18.9% in controls; p = 0.004).</p> <p>Conclusions</p> <p>People with haplogroup U have a lower risk to develop exfoliation glaucoma. Our results substantiate the suggestion that mitochondrial alterations have an impact on the etiology of glaucoma.</p>http://www.biomedcentral.com/1471-2156/11/8 |
| spellingShingle | Wissinger Bernd Pasutto Francesca Müller-Myhsok Bertram Gramer Eugen Wolf Christiane Weisschuh Nicole Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population BMC Genetics |
| title | Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population |
| title_full | Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population |
| title_fullStr | Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population |
| title_full_unstemmed | Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population |
| title_short | Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population |
| title_sort | mitochondrial haplogroup u is associated with a reduced risk to develop exfoliation glaucoma in the german population |
| url | http://www.biomedcentral.com/1471-2156/11/8 |
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