Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

Abstract The neurotransmitter serotonin, involved in the regulation of pain and emotion, is critically regulated by the 5‐HT1A autoreceptor and the serotonin transporter (5-HTT). Polymorphisms of these genes affect mood and endogenous pain modulation, both demonstrated to be altered in fibromyalgia...

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Bibliographic Details
Main Authors: Isabel Ellerbrock, Angelica Sandström, Jeanette Tour, Silvia Fanton, Diana Kadetoff, Martin Schalling, Karin B. Jensen, Rouslan Sitnikov, Eva Kosek
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Brain
Subjects:
Serotonin
GABA
Genetic polymorphisms
5‐HT1A
Serotonin transporter
Fibromyalgia
Online Access:https://doi.org/10.1186/s13041-021-00789-4

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