Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009
<p>Abstract</p> <p>Dengue is emerging as the most important mosquito borne viral disease in the world. In mainland China, sporadic and large outbreaks of dengue illness caused by the four serotypes of dengue virus (DENV-1 to DENV-4) have been well documented. Guangdong province is...
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| Format: | Article |
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BMC
2012-06-01
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| Series: | Virology Journal |
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| Online Access: | http://www.virologyj.com/content/9/1/125 |
| _version_ | 1818394176771850240 |
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| author | Jiang Tao Yu Xue-Dong Hong Wen-Xin Zhou Wei-Ze Yu Man Deng Yong-Qiang Zhu Shun-Ya Qin E-De Wang Jian Qin Cheng-Feng Zhang Fu-Chun |
| author_facet | Jiang Tao Yu Xue-Dong Hong Wen-Xin Zhou Wei-Ze Yu Man Deng Yong-Qiang Zhu Shun-Ya Qin E-De Wang Jian Qin Cheng-Feng Zhang Fu-Chun |
| author_sort | Jiang Tao |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Dengue is emerging as the most important mosquito borne viral disease in the world. In mainland China, sporadic and large outbreaks of dengue illness caused by the four serotypes of dengue virus (DENV-1 to DENV-4) have been well documented. Guangdong province is the major affected area in China, and DENV-1 has dominantly circulated in Guangdong for a long time. In this study, a family cluster of DENV-3 infection in Guangzhou was described. Three cases were diagnosed as dengue fever based on clinical manifestation, serological and RT-PCR assays. Two DENV-3 strains were isolated in C6/36 cells and the complete genome sequences were determined. Phylogenetic analysis revealed that the new DENV-3 isolates from the family cluster were grouped within genotype III. Considering the fact that several DENV-3 strains within genotype V were also identified in Guangzhou in 2009, at least two genotypes of DENV-3 co-circulated in Guangzhou. Careful investigation and virological analysis should be warranted in the future.</p> |
| first_indexed | 2024-12-14T05:57:03Z |
| format | Article |
| id | doaj.art-2e11305e32d547b59bb6439a30cfabad |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-14T05:57:03Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
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| spelling | doaj.art-2e11305e32d547b59bb6439a30cfabad2022-12-21T23:14:33ZengBMCVirology Journal1743-422X2012-06-019112510.1186/1743-422X-9-125Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009Jiang TaoYu Xue-DongHong Wen-XinZhou Wei-ZeYu ManDeng Yong-QiangZhu Shun-YaQin E-DeWang JianQin Cheng-FengZhang Fu-Chun<p>Abstract</p> <p>Dengue is emerging as the most important mosquito borne viral disease in the world. In mainland China, sporadic and large outbreaks of dengue illness caused by the four serotypes of dengue virus (DENV-1 to DENV-4) have been well documented. Guangdong province is the major affected area in China, and DENV-1 has dominantly circulated in Guangdong for a long time. In this study, a family cluster of DENV-3 infection in Guangzhou was described. Three cases were diagnosed as dengue fever based on clinical manifestation, serological and RT-PCR assays. Two DENV-3 strains were isolated in C6/36 cells and the complete genome sequences were determined. Phylogenetic analysis revealed that the new DENV-3 isolates from the family cluster were grouped within genotype III. Considering the fact that several DENV-3 strains within genotype V were also identified in Guangzhou in 2009, at least two genotypes of DENV-3 co-circulated in Guangzhou. Careful investigation and virological analysis should be warranted in the future.</p>http://www.virologyj.com/content/9/1/125Dengue virus type 3Family clusterGenotypeCo-circulation |
| spellingShingle | Jiang Tao Yu Xue-Dong Hong Wen-Xin Zhou Wei-Ze Yu Man Deng Yong-Qiang Zhu Shun-Ya Qin E-De Wang Jian Qin Cheng-Feng Zhang Fu-Chun Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009 Virology Journal Dengue virus type 3 Family cluster Genotype Co-circulation |
| title | Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009 |
| title_full | Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009 |
| title_fullStr | Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009 |
| title_full_unstemmed | Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009 |
| title_short | Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009 |
| title_sort | co circulation of two genotypes of dengue virus serotype 3 in guangzhou china 2009 |
| topic | Dengue virus type 3 Family cluster Genotype Co-circulation |
| url | http://www.virologyj.com/content/9/1/125 |
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