Induced Pluripotent Stem Cell-Derived Cardiomyocytes with <i>SCN5A</i> R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes

Induced Pluripotent Stem Cell-Derived Cardiomyocytes with <i>SCN5A</i> R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes

The <i>SCN5A</i> R1623Q mutation is one of the most common genetic variants associated with severe congenital long QT syndrome 3 (LQT3) in fetal and neonatal patients. To investigate the properties of the R1623Q mutation, we established an induced pluripotent stem cell (iPSC) cardiomyocy...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Emiko Hayama, Yoshiyuki Furutani, Nanako Kawaguchi, Akiko Seki, Yoji Nagashima, Keisuke Okita, Daiji Takeuchi, Rumiko Matsuoka, Kei Inai, Nobuhisa Hagiwara, Toshio Nakanishi
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: MDPI AG 2021-10-01
Ráidu:Biology
Fáttát:
<i>SCN5A</i>
Nav1.5
mutation
R1623Q
induced pluripotent stem cells
cardiomyocyte
Liŋkkat:https://www.mdpi.com/2079-7737/10/10/1062

Interneahtta

https://www.mdpi.com/2079-7737/10/10/1062

Geahča maid